Androgens Flashcards
1
Q
What is the most potent androgen?
A
DHT
2
Q
What are some actions of androgens?
A
- Promotes spermatogenesis
- Promotes lean body mass and skeletal muscle growth
- Reduces fat mass
- Growth of larynx
- Closure of the epiphyseal plates
- Puberty in females
- Erythropoiesis
3
Q
What is the effect of androgens on clotting factor?
A
Decreases synthesis of clotting factors
4
Q
What is the effect of estrogens on clotting factor?
A
Increases synthesis
5
Q
What are the consequences of decreased androgens in males?
A
- Decreased libido
- Decreased muscle mass
- Decreased axillary and pubic hair
- Anemia and osteoporosis
6
Q
What are the indications of androgens?
A
- HRT in hypogonadism
- Induction of puberty
- Osteoporosis in males
7
Q
What are some contraindications of androgens as HRT?
A
- Breast cancer in men
- Prostate cancer
- Pregnancy
8
Q
Flutamide MOA
A
Competitive antagonist of DHT and testosterone binding
9
Q
Flutamide Indications
A
- Metastatic prostate cancer
- BPH
10
Q
Flutamide SE
A
- Hepatotoxicity
- Diarrhea/Nausea
- Hematopoietic Diseases
11
Q
Flutamide Contraindication
A
Severe hepatic impairment
12
Q
Leuprolide MOA
A
GnRH agonist
13
Q
Spironolactone MOA
A
Inhibition of DHT and T binding
*Also is an aldosterone receptor antagonist
14
Q
Spironolactone Indications
A
- Hirsutism
- HTN
- Acne
- Edema from CHF
- Hypokalemia
15
Q
Spironolactone Contraindications
A
- Anuria
- Hyperkalemia
- Renal insufficiency
