Clinical Pharmacology and Therapeutics Flashcards
Cyclophosphamide MoA
T cell modulation
Adalimumab MoA
TNF alpha other TNF alpha golimumab used in psoriasis/psoriatic arthropathy
Trimethoprim effect on kidney
Can temporarily raise creatinine
Ciclosporin MoA
IL-2 production inhibitor
Notable side effect of tramadol
Serotonin syndrome
Primary mode of action of digoxin
intracellular sodium accumulation -> this in turn then pumps more calcium in in exchange for sodium which promotes myocardial contractility
MoA vincristine
mitotic inhibition -> acts on metaphase
COCP increases risk of which cancer?
Cervical cancer risk increased until about 10 years from moment that pill is stopped
Second dose of amiodarone in pulseless VT
150mg once five cycles of CPR done, first dose of 300mg given but still in pulseless VT
ACEi in pregnancy
Associate with birth defects -> stop and observe BP, start labetalol or methyldopa
Treatment secondary hypoparathyroidism
What is cinacalcet?
side effects of gold (smae as mtx)
pancytopenia and pulmonary fibrosis
SE of hydroxychloroquine
nausea and retinopathy rarely
THings to bare in mind with ribavirin treatment
Haemolytic anameia (drop of 20 points) so avoid in elderly.
Teratogenic so conception for 1 year after
SE of interferon therapy is flu like sx, emotional liability, mood changes and thyroiditis
Which drugs cause drug induced lupus?
MoA antiplatelets drugs
