Clinical Pharmacokinetics and Drug Dosing Part I Flashcards
1
Q
what is the equation for half-life?
A
0.693Vd/Cl
2
Q
what is the equation for rate of elimination?
A
Kel=Cl/Vd
3
Q
what is the equation for bioavailability?
A
bioavailability=area under the curve (oral)/area under the curve (iv)
4
Q
doubling the dose extends the therapeutic effect by ______________________
A
one half-life
5
Q
if you dose every half-life, trough is half the peak. if you dose every two half-lives, the trough is ____________ of the peak
A
1/4
