Approach to GI and Liver Therapy Flashcards
what can we use to treat inflammation (IBD, hepatitis)?
glucocorticoids
cyclosporin
what is budesonide?
locally acting glucocorticoid effective for GI disease
what infections might we treat in the GI and liver?
parasites
bacterial
viral
protozoal
what infections can we see with bacteria in the liver?
neutrophilic cholangitis in cats
bacterial cholecystitis in dogs, can be associated with mucoceles
what neoplasms are common in the GI and liver?
round cell tumors
what is the vomiting center?
lateral reticular formation in medulla oblongata
afferent sensory co-ordination
efferent signals to initiate vomiting
what receptors are in the emetic center?
alpha 2-adrenergic
serotonergic
NK-1
which receptors are peripheral for vomiting?
5HT3
NK-1
what do the effects of ondansetron appear to be mediated primarily by?
its antagonism of the peripheral receptors
what should you do if you are treating nausea/vomiting?
give maropitant citrate
if still nauseated, especially if GI is causing it: add ondansetron
if ileus/gastric distension: consider metoclopramide instead or with ondansetron
what is the drug of choice for megacolon in cats?
cisapride
when are antacids indicated?
known ulceration
NSAID toxicity
esophagitis
should you give an antacid to combat gastric hyperacidity in a patient that is not eating?
no
is ALP or ALT more specific for liver injury?
ALT
which glucocorticoids can we use to treat inflammation?
prednisone/prednisolone for liver and GI
budesonide common for GI
