Clinical Dermatology Flashcards
What do the ABCDE’s stand for?
A: asymmetry B: Border C: Color D: Diameter E: Evolving
What is the cause of chronic bullous disease of childhood?
Subset of linear IgA Bullous dermatosis
Autoimmune–> linear deposition of IgA at the basement membrane zone
What is the cause of linear IgA bullous dermatosis in adults?
idiopathic Drug induced (like vancomycin)
Do the blisters of pemphigus vulgaris occur high in the skin or low in the skin?
High- the antibodies are targeting desmoglein 1 and 3, which are part of desmosomes
Is pemphigus vulgaris life threatening?
Yes- due to fluid/electrolyte imbalances and risk of superimposed infection
What surfaces are often involved with dermatitis herpetiformis?
extensor surfaces, scalp, nuchal area, butt
What is the cause of dermatitis herpetiformis?
IgA deposition in the dermal papillae
In addition to drugs, what else can induce SJS in kids?
Mycoplasma
“Dewdrops on a rose petal” is the clinical description of what dermatitis?
chicken pox (varicella)
What is the most common complication of varicella?
secondary infection with staph aureus or strep
What causes staph scalded skin syndrome?
exfoliate toxin A, an active serine protease, breaks down the desmosomes
Name 4 areas psoriasis tends to occur on the body
gluteal cleft, nails, scalp, conchal bowls
What is atopic dermatitis?
Scaly round/oval plaque disease found in 20% of the kids in the U.S.
Associated with seasonal allergies, eczema, asthma….atopy…
How do we confirm a dermatophyte infection in tinnea corporis?
Scrape the leading edge of the scale and stain with KOH
-Look for septal hyphae
Herald patches describe what dermatitis?
Pityriasis Rosea
What is thought to be the cause of pityriasis rosea?
HHV 6/7
Human herpes virus
What is the distribution of patches in pityriasis rosea/
tends to follow tension lines –> christmas tree like
What is the prognosis of pityriasis rosea?
3-8 weeks, self-resolving
What do rashes from urticaria look like?
Raised, annular, erythematous- no epidermal changes (no plaques)
What are two ways to distinguish viral exanthems from drug exanthems?
Age: children get viral exanthems»_space; adults
Location: viral exanthems are concentrate on the extremities > trunk
What is erythema nodosum?
Tender indurated subcutaneous nodules that tend to appear on the pretibial area and lateral shins
SEPTAL panniculitis
What are a few causes of erythema nodosuM
Infection, drugs, OCP, echinacea
inflammatory diseases
What are the common organisms causes cellulitis?
Staph, strep
Does morbilliform drug exanthem localize on the trunk or extremities?
Trunk > extremities
