Clinical Flashcards
Explain multiple sclerosis
autoimmune disorder resulting in degradation of myelin in CNS
What blocks neurotransmitters release?
Botulinum and tetanus toxins
Parkinson’s disease
Death of midbrain dopamine neurons causing motor and cognitive deficits
Involvement of forehead means :
Lower Motor Neuron lesion
Bradykinesia, rigidity, postural instability, +/- tremor
Parkinson’s disease
Major Depressive Disorder Dx
5 or more symptoms from DSM in 2 weeks, representing a change from previous functions, and a least of the symptoms is depressed mood or loss of interest/pleasure.
Key points for psychiatric disorders dx
5 or more symptoms
in a specific timeline
rule out other psychiatric (eg alcoholism) and physiologic (having a cancer) causes
Causes functional impairment
Psychiatric interview format
1) Introduction
2) Opening (ID, chief complaint)
3) Body (extend HPI, summarize, get collateral, screening for other disorders)
4) Closing (dx, tx options discussed)
What to look for in speech for psychiatric interview ?
Rate, rhythm and volume
What to look for in mood and affect for psychiatric interview?
Self reported subjective emotional experience
Overal pattern and type of emotional states and expression
What to look for in thought process for psychiatric interview?
Connection & speed
What to look for in thought content for psychiatric interview?
Homocidal/suicidal ideas Obsessions Overvalued ideas Idea of reference Delusions
What to look for in perception for psychiatric interview?
Illusion
Hallucination
Dissociation
Visual hallucinations
Usually medical causes but can occur in schizophrenia
What to look for in cognition for psychiatric interview?
Level of consciousness Orientation to person, time and place Attention Memory Overall intelligence Use MMSE or MOCA
Psychiatric interviewing MSE
appearance behavior cooperation mood & affect speech thought process thought content perception cognition judgment insight risk assessment
Acute Schizophrenia treatment
Antipsychotic medication
Consider clozapine or other injectable medication
Chronic Schizophrenia tx
Psychotherapy (CBT)
Supported employment/social skills
Major depressive disorder tx
Antidepressant and/or psychotherapy
Possibly ECT
Bipolar disorder tx
Manic : lithium/mood stabilizer + antipsychotic
Depressed : NO ANTIDEPRESSANTS, lithium/mood stabilizer + psychotherapy +/- antipsychotics
Maintenance (mood stabilizer) + psychoeducation and relapse prevention
Anxiety disorder tx
Psychotherapy (CBT) Possible antidepressants (SSRIs/SNRIs)
Personality disorders tx
psychotherapy
Substance use tx
Psychotherapy/counselling
Peer support
Medication depending on drug
Enlarged 4th ventricle
communicating hydrocephalus (reabsorption)
No communication of CSF with sub-arachnoid space
All ventricles except the 4th are enlarged
non communicating hydrocephalus (obstruction)
Congenital hydrocephalus
Non communicating (aqueduct stenosis, blood)
Communicating (arachnoid villi absent, blood/pus)
Acquired Hydrocephalus
Non communicating (blood, tumor, pus)
Communicating (blood/pus)
Examination of nervous system order
Mental Status Language Cranial nerves Motor (bulk, tone, power, arms & legs) Reflexes Coordination Sensation Gait
Attention in delirium
impaired
Attention in dementia
preserved until late
Hierarchy of basic cognitive functions
- Attention
- Appropriate
- Alert
- Awake
Language testing
fluency naming comprehension repetition reading writing
Pupillary light reflex CN involvement
CN II and III
Corneal reflex CN involvement
CN V and VII
Gag reflex CN involvement
CN IX and X
Motor exam
Bulk
Tone
Power
Spasticity
Velocity dependent
Feel a spastic catch
Rigidity
Not velocity dependent
Constant
Feel a cog-wheel quality
Increased reflexes
UMN
Decreased reflexes
LMN
Decreased Muscle bulk
LMN
Increased Muscle tone
UMN
Decreased muscle power
both UMN and LMN
Positive Babinski
UMN
Negative Babinski
LMN
Fasciculations
LMN
Biceps reflex nerve root
C5
Triceps reflex nerve root
C7
Brachioradialis reflex nerve root
C6
Patellar reflex nerve root
L3/4
Achilles reflex nerve root
S1
Sensory testing
- Pin-Prick (pain)
- Temperature
- Joint position/vibration
- Sensory testing
Gait testing
- Stance/base
- Symmetry height, step length
- Hip, knee & ankle flexion
- Arm swing
- Pivot
Romberg test
Eyes closed : cerebellar or proprioceptive problem
Eyes open : cerebellar