Clindamycin Flashcards
what drug group is clindamycin?
lincosamide
what bacteria is it effective against?
broad range of positive and negative
how does clindamycin kill bacteria? at what site?
inhibits protein synthesis
50S ribosomal unit
half life?
3 hrs
list unwanted effects of clindamycin
nausea/vomiting
abdominal pain
glossitis
stomatitis
oesophagitis
allergy
metallic taste
maculopapular rash
diarrhoea
pseudomembranous colitis - potentially fatal
what can be used to treat pseudomembranous colitis as a result of clindamycin use?
vancomycin or metronidzole
give 2 drug reactions of clindamycin
anti-diarrhoeal drugs - slow absorption
erythromycin
when is clindamycin indicated?
Orofacial infections
Penicillin allergy
If infection not resolving w/ penicillin or metronidazole use
If pt beta lactam resistant
what does BNF & SDCEP say about clindamycin use?
should not be used routinely:
Its no more effective than penicillin
Cross resistance w/ erythromycin resistant bacteria
when is clindamycin contraindicated?
if pt has allergy to it
dose?
150-300mg every 6 hrs
length of course?
3-5 days
route of administration?
oral
loading dose?
no
when to cease use?
if pt has diarrhoea
