Aspirin

Question 1

give another name for aspirin

Answer 1

Acetylsalicylic acid

Question 2

where can aspirin dissolve/not dissolve?

Answer 2

can dissolve in solution but not in mouth

Question 3

what can aspirin be used to tx?

Answer 3

anypyrexic - txs fever
antiplatetelt/thrombotic
anti-inflammatory
analgesic for mild-moderate pain
regulates BP

Question 4

what does aspirin inhibit?

Answer 4

COX 1, 2 & 3

Question 5

what does COX 1 & 2 binding do?

Answer 5

COX 1 - causes adverse effects
COX 2 - antiinflammatory

Question 6

half life?

Answer 6

20-30 mins

Question 7

how does it bind to platelets?

Answer 7

irreversibly

Question 8

how can it affect pregnancy?

Answer 8

can cross placenta and evidence in breast milk

Question 9

list indications for aspirin

Answer 9

acute pain
dental pain
rheumatic fever
rheumatoid arthritis
other inflammatory diseases
fever
acute coronary syndrome/ischemic stroke
anti-thrombotic

Question 10

list complications of aspirin

Answer 10

AERD = aspirin exacerbated resp disease
GI issues
3x inc chance of renal failure
Haematological
gout
tinnitus
skin reactions
pregnancy
glycaemic control
prostaglandin inhibition
reye’s syndrome

Question 11

what age should aspirin be avoided?

Answer 11

<16yrs

Question 12

what is considered an aspirin overdose? (g)

Answer 12

10-30g

Question 13

list symptoms of an aspirin overdose

Answer 13

CO2 production in skeletal muscle causing:
hyperventilation
hyperthermia
dehydration
tinnitus
deafness
vasodilations
sweating

Question 14

what drugs should aspirin be avoided alongside?

Answer 14

AAANTS:
Anticoagulants
Antihypertensives
Antiepileptics
NSAIDs
Thrombocytes
Steroids

Question 15

what is the standard dose for an adult? max dose?

Answer 15

300-900mg every 4-6hrs
max 4g per day
preferably w/ food