Clin Path 3 Flashcards
muscle (smooth, skeletal and cardia)
shuttle phosphate between ATP and ADP
when muscle is injured this escapes
cell injury
increase fast, decrease fast
Creatine Kinase (CK)
CK does not equal CR
cell injury
liver and muscle
hemolysis (RBC)
large and small animals
T1/2 <24h dogs and cats
T1/2=7-10 days in horse
AST
cell injury
liver
replace ALT for large animal
best liver injury marker
hepatocytes injury
T1/2=hours
SDH
cell injury
liver specific for small animals
little in muscles for dogs with increase in CK
T1/2=2.5d (dog) 3.5h (horse)
ALT
large and small
induced
hepatobiliary
cholestasis-decreased bile flow
GGT
small animal
induced
hepatobiliary
cholestasis-decreased bile flow
dogs only-cALP. drug induced production, corticosteroids, phenobarbital
ALP
cell injury-non specific
exocrine pancreases (pancreatitis)
T1/2=2h (Dog)
in junction with amylase
pancreatitis-increased 3-8x
corticosteroid-increased 5x
LPS
Cell injury
specific for exocrine pancrease than LPS
PLI
pancreatic lipase immunoreactivity
cPLI-most sensitive and specific for canine pancreatitis
cell injury
exocrine pancreases (pancretitis) and other tissue types
digest starch
excreted by kidney
if glomerular filtration bad, this increased
AMS
CK-increased
ALT-norm
ALP-norm
GGT-norm
AMS-norm
LPS-norm
SM animal muscle injury
CK-norm
ALT-increased
ALP-norm
GGT-norm
AMS-norm
LPS-norm
sm animal hepatic injury
CK-norm
ALT-norm
ALP-increased
GGT-increased
AMS-norm
LPS-norm
SM animal cholestasis
CK-norm
ALT-increased
ALP-increased
GGT-increased
AMS-norm
LPS-norm
Sm animal
hepatic injury with cholestasis
CK-norm
ALT-norm
ALP-norm
GGT-norm
AMS-increased
LPS-increased
sm animal
pancreatic injury
CK-increased
AST-increased
SDH-norm
GGT-norm
LG animal
muscle injury
