Classification of Tumours (week 9) Flashcards

1
Q

Suffix for benign epithelial tumour

A

-oma

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2
Q

If the tumour is in the surface epithelium, how is it further identified?

A

describe cell type, e.g. squamous cell

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3
Q

If the tumour is in glandular epithelium, how is it further identified?

A

describe glandular tissue, e.g. colonic adenoma

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4
Q

Suffix for malignant epithelial tumour

A

carcinoma

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5
Q

Malignant tumour dervied from secretory epithelium

A

adenocarcinoma

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6
Q

Suffix for benign mesenchymal tumour

A

-oma

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7
Q

Suffix for malignant mesenchymal tissue

A

sarcoma

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8
Q

Mesenchymal definition

A

Skeletal / connective tissue

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9
Q

Smooth muscle prefix

A

leiomyo

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10
Q

Skeletal muscle prefix

A

Rhabdomyo

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11
Q

Adipose tissue prefix

A

Lipo

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12
Q

blood vessel prefix

A

angio

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13
Q

bone prefix

A

osteo

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14
Q

cartilage prefix

A

chondro

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15
Q

fibrous prefix

A

fibro

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16
Q

Haematological Malignancies:

1) Leukaemia
2) Lymphoma
3) Myeloma

A

1) bone marrow
2) lymphocytes
3) plasma cells

17
Q

Benign tumour of glandular epithelium of thyroid

A

Thyroid adenoma

18
Q

Benign tumour of bone

19
Q

Benign tumour of adipose tissue

20
Q

Malignant tumour of basal cells of skin

A

Basal cell carcinoma

21
Q

Malignant tumour of Stratified squamous epithelium

A

Squamous cell carcinoma

22
Q

Malignant tumour of fibrous tissue

A

Fibrosarcoma

23
Q

Malignant tumour of smooth musle

A

Leiomyosarcoma

24
Q

What is the difference between initiator and promoter carcinogens?

A

Initator is genotoxic, modifies / damages DNA

Promoter induces proliferation and DNA replication

25
Name some common genetic abnormalities that initiator carcinogens may cause.
Point mutations Additiion / deletion causing frameshift mutation Gene amplification to give up to 100 copies of a gene that normally only has 2 Translocation: genes moved to a more transcriptionally active region or being combined into new gene fusions
26
What is the Philadelphia translocation?
chr9:22 translocation associated with chronic myeloid leukaemia
27
What is an oncogene?
Gain of function caused by mutation which confers a tumour characteristic to a cell
28
How are tumour suppressor genes implicated in tumour generation?
Inactivated by mutation to allow uncontrolled cell growth
29
What is a proto-oncogene?
Non-mutated version that precedes an oncogene
30
What is a procarcinogen?
When metabollically activated by enzymes, becomes a carcinogen
31
List some defence mechanisms against carcinogens.
``` Antioxidants Detoxification mechanisms DNA repair enzymes Apoptosis of unrepaired genetic damage Immune response to abnormal cells ```
32
How does alcohol act as a carcinogen?
Converted into acetaldehyde which can cause DNA damage Increases levels of oestrogen and testosterone Increases uptake of carcinogenic chemicals Reduces folate needed for DNA replication Kills surface epithelium leading to unscheduled proliferation