classical conditioning- lecture 2

Question 1

what are the three basic techniques for establishing circuitry of the cerebellum

Answer 1

Neuroanatomy- tract tracing: retrograde amnesia, anterograde amnesia.

Electrophysiology- what signals are carried by these connections. Record from individual neurons when animal presented with sensory stimuli (hubel and Wiesel)

Manipulation- removal, inactivation or stimulation.

Question 2

what is the unconditioned reflex pathway?

Answer 2

cornea- (trigeminal nerve V, cell bodies in Gasserian ganglion)- spinal trigeminal nucleus (oral subdivision)- accessory abducens nucleus- retractor bulbi muscle.

Question 3

conditioned response circuit

Answer 3

lobule HV1 of the cerebellar cortex inhibits the anterior interpositus nucleus which travels via the red nucleus to the accessory abducens nucleus

Question 4

evidence for anterior interpositus nucleus

Answer 4

Deep cerebellar nuclei lesions block conditioning, lesions confined to the anterior interpositus nucleus effective.