classic labs/findings 1 Flashcards
anti-centromere Abs
Scleroderma (CREST)
Anti-desmoglein (epithelial) Abs
Pemphigus vulgaris (blistering)
Anti-glomerular basement membrane Abs
Goodpasture’s syndrome
glomerulonphritis and hemoptysis
Anti-histone Abs
Drug-induced SLE
hydralazine, isoniazid, phenytoin, procainamide
Anti-IgG Abs
Rheumatoid arthritis (systemic inflammation, joint pannus, boutonniere deformity)
Anti-mitochondrial Abs (AMAs)
primary biliary cirrhosis
female, cholestasis, portal HTN
c-ANCAs
granulomatosis w/ polyangiitis
p-ANCAs
microscopic polyangiitis, Churg Strauss syndrome, primary sclerosing cholangitiis
ANAs: anti-Smith and anti-dsDNA
SLE (type III HSR)
anti-platelet Abs
idiopathic thrombocytopenic purpura
anti-topoisomerase Abs
diffuse systemic scleroderma
anti-transglutaminase;
anti-gliadin;
anti-endomysial Abs
Celiac disease
diarrhea, distention, weight loss
Apple core lesion on abdominal X ray
colorectal cancer (usually Left sided)
Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts
Auer rods (AML, especially promyelocytic M3 type)
Bacitracin response
Sensitive: Streptococcus pyogenes (group A)
Resistant: Streptococcus agalactiae (group B)
Bamboo spine on x ray
ankylosing spondylitis
chronic inflammatory arthritis: HLA-B27
Basophilic nuclear remnants RBCs
Howell-Jolly bodies
due to splenectomy or nonfxnal spleen
Basophilic stippling of RBCs
Lead poisoning or sideroblastic anemia
Bloody tap on LP
subarachnoid hemorrhage
Boot shaped heart on CXR
tetralogy of Fallot;
RVH
branching gram pos rods w/ sulfur granules
Actinomyces israelii
Bronchogenic apical lung tumor on imaging
Pancoast tumor
can compress sympathetic ganglion & cause Horner’s syndrome
“Brown” tumor of bone
Hyperparathyroidism or osteitis fibrosa cystica
deposited hemosiderin from hemorrhage gives brown color
Cardiomegaly w/ apical atrophy
Chagas’ disease (Trypanosoma cruzi)
Cellular crescents in Bowman’s capsule
Rapidly progressive crescentic glomerulonephritis
“chocolate cyst” of ovary
Endometriosis (frequently involves both ovaries)
Circular grouping of dark tumor cells surrounding pale neurofibrils
Homer-Wright rosettes
neuroblastoma, medulloblastoma, retinoblastoma
colonies of mucoid Pseudomonas in lungs
Cystic fibrosis (AR mutation in CFTR resulting in fat-soluble vitamin deficiency and mucous plugs)
Decreased alpha-fetoprotein in amniotic fluid/maternal serum
down syndrome or other chromosomal abnormality
degeneration of dorsal column nerves
Tabes dorsalis (3' syphilis), subacute combined degeneration (dorsal columns & lateral corticospinal tracts affected)
depigmentation of neurons in substantia nigra
Parkinson’s disease
basal ganglia disorder: rigidity, resting tremor, bradykinesia
desquamated epithelium casts in sputum
Curschmann’s spirals (bronchial asthma; can result in whorled mucous plugs)
disarrayed granulosa cells in eosinophilic fluid
Call-Exner bodies
granulosa-theca cell tumor of the ovary
dysplastic squamous cervical cells w/ nuclear enlargement and hyperchromasia
Koilocytes
HPV: predisposes to cervical cancer
enlarged cells w/ intranuclear inclusion bodies
“Owl’s eye” appearance on CMV
enlarged thyroid cells w/ ground glass nuclei
“orphan annie’s eyes” nuclei
papillary carcinoma of thyroid
eosinophilic cytoplasmic inclusion in liver cell
Mallory bodies (alcoholic hepatitis: reversible)
eosinophilic cytoplasmic inclusion in nerve cell
Lewy body (Parkinson’s disease)
eosinophilic globule in liver
Councilman body
toxic or viral hepatitis, often yellow fever
eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Negri bodies of rabies (Lyssavirus)
extracellular amyloid deposition in gray matter of brain
Senile plaques (Alzheimer’s disease)
Giant B cells w/ bilobed nuclei w/ prominent inclusions (owl’s eye)
Reed-Sternberg cells (Hodgkin’s lymphoma)
Glomerulus-like structure surrounding vessel in germ cells
Schiller-Duval bodies (yolk sac tumor)
“hair on end” (crew-cut) appearance on x ray
Beta-thalassemia,
sickle cell anemia (marrow expansion)
hCG elevated
choriocarcinoma, hydatidiform mole (occurs w/ and w/o embryo)