Class 5: Autoimmune disorders

Question 0

Systemic Lupus Erythromatosus

Answer 0

Lupus

Malfunction of T suppressor cells which allows polyclonal activation of B cells.

Resultant plasma cells secrete auto-AB

Ab-Ag complexes circulate to other membranes and active complement –> inflammatory diseases.

Question 1

Diagnosis of AI disorders based on

Answer 1

Existence of auto-AB
Evidence that immune mechanism causing pathological lesion.
Evidence of immune nature of disorder.

Question 2

Clinical features of SLE

Answer 2

Highly variable
Butterfly rash
Joint inflammation
Kidney malfunction, anemia

Question 3

What characterizes all immunodeficiency diseases?

Answer 3

Lymphopenia (Low lymphocyte count in peripheral blood)

Question 4

DiGeorge’s syndrome

Answer 4

Primary immunodeficiency disease

Aplasia of thymus and aplasia of parathyroid glands.

Question 5

AIDS

Answer 5

Acquired immune deficiency syndrome
Caused by HIV

Affinity for T helper cells and monocytes, macrophages, microglia.

Cytotoxic. Destroys T cells. Depresses cell mediated immunity

Question 6

Phases of HIV/AIDS

Answer 6

Phase of Acute Illness (Group I)
Phase of Asymptomatic infection (Group II)
Phase of Generalizes Lymphadenopathy (Group III)
AIDS (Group IV) (CD4 decrease)

Question 7

Diagnosis of AI disorders based on

Answer 7

Existence of auto-AB
Evidence that immune mechanism causing pathological lesion.
Evidence of immune nature of disorder.

Question 8

Systemic Lupus Erythromatosus

Answer 8

Lupus

Malfunction of T suppressor cells which allows polyclonal activation of B cells.

Resultant plasma cells secrete auto-AB

Ab-Ag complexes circulate to other membranes and active complement –> inflammatory diseases.

Question 9

Clinical features of SLE

Answer 9

Highly variable
Butterfly rash
Joint inflammation
Kidney malfunction, anemia

Question 10

What characterizes all immunodeficiency diseases?

Answer 10

Lymphopenia (Low lymphocyte count in peripheral blood)

Question 11

DiGeorge’s syndrome

Answer 11

Primary immunodeficiency disease

Aplasia of thymus and aplasia of parathyroid glands.

Question 12

AIDS

Answer 12

Acquired immune deficiency syndrome
Caused by HIV

Affinity for T helper cells and monocytes, macrophages, microglia.

Cytotoxic. Destroys T cells. Depresses cell mediated immunity

Question 13

Phases of HIV/AIDS

Answer 13

Phase of Acute Illness (Group I)
Phase of Asymptomatic infection (Group II)
Phase of Generalizes Lymphadenopathy (Group III)
AIDS (Group IV) (CD4 decrease)

Question 14

Cancers most associated with AIDS

Answer 14

Kaposi’s sarcoma and lymphomas

Question 15

Amyloidosis

Answer 15

Multifactorial disease caused by abnormalities of the immune system or abnormal response to chronic infection.

Marked by a build-up of amyloid in tissues, usually in extra-cellular spaces.

Systemic or local

In brain –> Alzheimer’s

Question 16

Amyloid

Answer 16

A fibrillin protein formed into a beta pleated sheet.