Citric Acid Cycle Flashcards
What are the three major stages of cellular repsiration?
- Acetyl CoA production
- Acetyl CoA oxidation
- Electron transfer and oxidative phosphorylation
What is Citrate?
A tricarboxylic acid
What occurs in stage 1 of respiration?
Production of acetyl CoA from glucose, amino acids and faty acids
What is stage 2 of respiration?
Acetyl groups are oxidised in the Citric Acid Cycle (CAC)
What energy are generated as a result of stage 2 in respiration?
NADH, FADH2, ATP, GTP
What is stage 3 of respiration?
NADH and FADH2 can donate electrons to the electron transfer chain generating ATP
Where does Glycolysis occur?
Cytosol
Where does Citric acid cycle occur?
Mitochondrial matrix
Where does Oxidative phosphorylaion occur?
Inner membrane in the mitochondria
What is the execpion to reacting in the mitochondrial matrix?
Succinate dehyrogenase, occurs in the inner membrane
What catalyses the conversion of pyruvate to Acetyl-CoA?
Pyruvate decarboxylase complex
What is the net reaction to the conversion of pyruvate to Acetyl-CoA?
Oxidative decarboylation of pyruvate
What type of reaction is oxidative decarboxylation of pyruvate?
Irreversible reaction
What are the five coenzymes for th epyruvate dehydrogenase complex?
- Thiamine pyrophosphate (TPP)
- Lipoic acid
- FAD
- CoA
- NAD+
What are the coenzymes that help with catalytic activity in pyruvate dehydrognease complex?
- Thiamine pyrophosphate
- Lipoic acid
- FAD
What are the coenzymes that help function as substrates in pyruvate dehydrognease complex?
- CoA
- NAD+
What occurs to those that are unable to process pyruvate?
It accumulates in their blood
What occurs to NADH and FADH2 in he Citric Acid Cycle?
Becomes reduced (FAD and NAD+)
What are Anapleroic Reactions?
Replenishes meabolites for the cyle
What happens in Anaplertoic Reactions?
Four carbon intermediates formed by carboxylation of three-carbon precursors
GO OVER THE DIAGRAMS TO LECTURE 16 SLIDES
