CIS Things Flashcards

1
Q

What is a Gartner duct cyst?

A
  • on superior vag wall
  • no mucus formation
  • lined with cuboidal and low columnar epithelium
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2
Q

What is pseudomyxoma peritonei associated with?

A

-appendiceal tumor

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3
Q

What is a Gartner duct cyst a remnant of?

A

-mesonephric ducts

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4
Q

What are the gram + rods that are non spore forming in the vaginal canal?

A

-lactobacillus

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5
Q

What does Chlamydia look like on gram stain?

A

-gram - cocci

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6
Q

What does neisseria look like on gram stain?

A

-Gram- diplococci

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7
Q

What is the buzzword for HSV?

A
  • cowdry bodies

- also true for CMV

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8
Q

What are clue cells associated with?

A
  • gardnerella vaginalis

- it’s just like a squamous cell, but the bacteria are attacking

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9
Q

What are cytoplasmic viral inclusions associated with?

A

-MCV (Molluscum contagiosum)

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10
Q

What is is the buzzword for chlamydia?

A
  • elementary bodies: non replicating infectious particles

- reticulate bodies: bacteria replicating inside the cell… non infectious tho

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11
Q

What is the buzzword for HPV?

A
  • koilocytes

- squamous epithelium with hyperchromatic nucleii with a perinuclear halo

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12
Q

What is a common coinfection with neisseria gonorrhoea?

A
  • Chlamydia

- do NAAT to figure out which one it is

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13
Q

What agar would be diagnostic for someone who we think might have gonorrhoae?

A

-Thayer-Martin Agar

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14
Q

What will grow on chocolate agar?

A
  • Neisseria

- and other things like hemophilus

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15
Q

What is it called when you have PID and it spreads up into the peritoneal cavity?

A

-Fitz Hugh Curtis syndrome

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16
Q

What is aortitis associated with?

A
  • syphillis

- so is argyll robertson pupils

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17
Q

If a girl with Gonorrhea gets preggo, what will we have to worry about in the baby?

A
  • rapid onset conjuctivitis

- later onset is chlamydia

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18
Q

What is associated with a baby who has saber shins and mullberry molars (hutchinson teeth)?

A

-syphillis (T. pallidum)

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19
Q

If a woman has itchy hyperkeratosis and acanthosis, what do we think of?

A

-squamous cell hyperplasia

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20
Q

If there is a grapelike mass in a child, what do we think of?

A

-embryonal rhabdomyosarcoma

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21
Q

If there is a grapelike mass in a 52 year old woman, what do we think of?

A

-endometrium and cervical polyps

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22
Q

What smear do we use to diagnose herpes?

A

-tznack smear

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23
Q

What organism will give us condyloma lata as a secondary lesion?

A

-T. pallidum

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24
Q

What organism is associated with donovan bodies?

A
  • Klebsiella granulomatis
  • blue on histo
  • africa
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25
Q

What is elephantiasis associated with?

A

-K. granulomatis

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26
Q

What is a soft chancre associated with?

A

-H. ducreyi

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27
Q

When I say strawberry cervix, you say….

A

-Trichomonas vaginalis

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28
Q

Koliocytes?

A

-HPV

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29
Q

Clue cells

A

gardnerella

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30
Q

warthin starry stain shows us what?

A
  • spiral shaped organisms

- T. pallidum

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31
Q

What is the major virulence factor for Gonorrhoea?

A

-pili

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32
Q

What ovarian finding is most likely due to neisseria infection?

A

-Abscess!

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33
Q

When I say streak ovary, you say….

A

-Turner Syndrome

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34
Q

When I say porcelain gallbladder, you say…

A

-gallbladder carcinoma

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35
Q

What is a cambium layer associated with?

A
  • sarcoma botryoides (embryonal rhabdomyosarcoma)

- these invade the retroperitoneum a lot

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36
Q

What is DES associated with?

A

-clear cell carcinoma of the vagina

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37
Q

What is the other organ that has a big clear cell tumor?

A

-the kidney!

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38
Q

What is adenocarcinoma of the cervix related to?

A

-HPV

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39
Q

What is endometrial carcinoma type 1 associated with?

A
  • unopposed estrogen
  • obesity
  • hypertension
  • diabetes
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40
Q

So if there is a huge pink mass in the uterus and there is a snowstorm pattern on ultrasound, what are we thinking of?

A

-Complete mole!

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41
Q

pseudomyxoma peritonei

A

-appendiceal tumor

-

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42
Q

What does IgG4 sclerosing disease cause?

A
  • fibrosis of the retroperitoneum

- Ormnod’s disease

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43
Q

In this section, when we hear psamomma bodies, what do we think?

A
  • serous ovarian tumors
  • think malignant
  • also with papillary thyroid carcinoma
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44
Q

What are call-exner bodies associated with?

A

-granulosa cell tumor

45
Q

What do granulosa cells secrete?

A
  • estrogen

- so watch out for uterine carcinoma or something like that

46
Q

When we see schiller duval bodies, what do we think of?

A
  • yolk sac tumors

- also see a glomeruloid lesion***

47
Q

What do we think of if there is a lot of 5-HIAA?

A
  • some kind of carcinoid tumor…

- monodermal teratoma

48
Q

Where is the most common site of a carcinoid tumor?

A

-jejunum or ileum

49
Q

What do yolk sac tumors secrete?

A

-alpha-fetoprotein!

50
Q

What do we use to track granulosa cell tumors?

A
  • inhibin!

- they secrete this along with estrogen

51
Q

What else will be there if we have a granulosa cell tumor?

A
  • a breast lesion

- makes sense because there is a lot of estrogen floating around

52
Q

What color will the tumor be if it is secreting a lot of hormones?

A

-yellow

53
Q

What is the ovarian counterpart of the most common male germ cell tumor?

A

-dysgerminoma

54
Q

What gene is associated with a dysgerminoma

A

KIT

55
Q

What serous tumors of the ovary uni or bilateral?

A

-bilateral

56
Q

What is the most common karyotype for a complete mole?

A
  • 46 XX…

- same as for mature teratomas in the ovary

57
Q

What karyotype is a partial mole?

A

-69XXX

58
Q

What do we associate squamous metaplasia of lactiferous ducts with?

A

-ciggareettes

59
Q

what is fat necrosis of the breast from?

A

-breast trauma

60
Q

What might happen to the breast during preggo?

A

-acute mastitis

61
Q

What is Li Fraumeni syndrome?

A

-TP53 germline mutation

62
Q

What is Cowden syndrome?

A

-mutation of PTEN

63
Q

what is Peau-d’orange associated with?

A
  • inflammatory carcinoma
  • lymphatic infiltration
  • younger age
  • poor prognosis
  • nipple inversion usually happens
64
Q

What is associated with inflitrating signet ring cells?

A
  • lobular carcinoma
  • if it’s e cadherin positive, then it’s ductal
  • if e cadherin negative, then lobular
65
Q

what is the leaf like growth pattern tumor called?

A
  • phylloides tumor

- it’s benign

66
Q

Why would a herpes patient have a positive RPR?

A
  • means she also has lupus!

- RPR reacts to that as well

67
Q

What is RPR normally used for

A

syphillis detection

68
Q

So if a lady has herpes and is placed on famciclovir, then returns as miscarriage at 8 weeks into preggo at a later time, what is the cause?

A

-disorder affecting maternal vasculature

69
Q

If we are in africa and the lady presents with draining inguinal lymph nodes, what would we most likely see on pap smear?

A

-chancroid (H. ducreyi)

70
Q

What are the STI’s with ulcers?

A
  • HSV
  • syphyllis (T. pallidum)
  • Chancroid (H. Ducreyi)
  • LGV (C. trachomatis)
  • Granuloma inguinale (K. granulomatis
71
Q

What is lumpy white discharge out of the vag in an older woman associated with?

A
  • type 1 DM

- band like lymphocytic infiltrate

72
Q

What do we think of when we see pale, PAS+ epidermal cells on the vulva?

A

-extramammary paget disease

73
Q

If there is labial swelling, what is it?

A

-bartholin gland abscess

74
Q

Where is a skene gland cyst?

A

-by the urethra

75
Q

What is the most common complication with Neisseria gonnorhoea infection in a woman?

A
  • ectopic pregnancy

- because of the scarring of the tubes from ascending infetion

76
Q

If there is perianal lesions on a girl, what is it most likely?

A
  • condyloma acuminatum

- HPV 6, 11

77
Q

Buzzword for molluscum contagiosum?

A
  • dimpled pearly papule lesion

- very common and associated wtih scarring in a lot of pts

78
Q

If someone has HPV, what will their pap smear look like 2 years down the road?

A
  • normal

- 90% of low grade HPV will resolve in 2 years

79
Q

What finding in the cervix will show up if a girl has recently had a low grade HPV infection?

A

-LGSIL

80
Q

what is the main difference between High and low grade squamous intraepithelial lesions?

A
  • how much they persist
  • LGSIL: 30%
  • HGSIL: 60%
81
Q

If a girl has herpes, what do we treat it with?

A

-Acyclovir

82
Q

What is azithromycin?

A

-an antibiotic

83
Q

What is metronidazole

A

-an anti amoebic agent

84
Q

What do the drugs end in if we use them to treat viruses?

A

“vir”

85
Q

What drug is used for CMV?

A

-Gancyclovir

86
Q

What is used to treat influenza?

A

-oseltamivir

87
Q

Will antiviral drugs screw up a pregnancy?

A

-no not likely

88
Q

If we treat someone with herpes with acyclovir and then they develop recurrent infetions, what is the most likely cause of this problem?

A
  • resistance to acyclovir…

- viruses that lack thymidine kinase activity will not be killed by the drug

89
Q

What contributes to gancyclovir resistance?

A

-U97 phosphotransferases

90
Q

If a lady has painful inguinal lympho nodes and showed chronic inflammation from a red lesion on the cervix and there is lots of endarteritis
-biopsy showed a lot of plasma cell infiltrates…. what is the organism?

A

-T. Pallidum

91
Q

What stain would we use for TB?

A

-Ziel Neelsen

92
Q

What stain do we use for herpes?

A

-Tzanck smear

93
Q

What do we use the silver stain for?

A

-Syphillis! T. pallidum

94
Q

What would signify progression of a syphillis infection

A

-palmar rash

95
Q

What do you treat a syphillis infection with?

A

-Penicillin G

96
Q

What does vancomycin not work on?

A

-Gram negative things

97
Q

Why wouldn’t gentimicine work for syphillis infection?

A

-it can’t get to the CNS

98
Q

What do we give a syphillis patient if they are allergic to penicillin?

A

-erythromycin

99
Q

24 y/o girl from Paris with a swollen painful knee

  • hemorrhagic papules on lower extremity,
  • joint aspiration has lots of cloudy fluid… lots of PMN’s
  • what is this most likely due to?
A

-Membrane attack complex

100
Q

What is the drug of choice for the last case?

A
  • ceftriaxone

- it penetrates into a lot of areas so it’s a good choic

101
Q

Which drug would provide coverage for the co-infecting pathogen that accompanies the disseminated disease from the parisian girl with the swollen knee?

A
  • the accompanying organism is Chlamydia

- so give them some doxycycline as well

102
Q

What will a baby have if it is born from a mom who has gonorrhoea?

A

-immediate onset conjunctivitis

103
Q

What if a baby comes from a chlamydia mom?

A
  • trachoma

- this is the later onset conjunctivitis

104
Q

What if a baby comes from syphillis mom?

A

-8th nerve deafness

105
Q

21 y/o requests birth control and then has mucopurulent discharge from cervical os.

  • no inflammation
  • no organisms
  • nothing shows up on gram stain
  • what is it?
A
  • Chlamydia type L

- Elementary body is infectious

106
Q

What is the most common cureable STI and how do we treat it?

A
  • trichomonas vaginalis

- treat with metronidazole

107
Q

What organism is treated with tinidazole?

A
  • giardia lamblia

- there is a lot of resistance to metronidazole in giardia, but not trichomonas

108
Q

What do we treat crabs with?

A
  • pyrethrins

- extracted from the chrysanthemum flower