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CIS Flashcards

1
Q

24 year old F. Vesicles bilaterally on labia majora. A few around urethral meatus. Mild inguinal adenoapthy present. Most likely?

A

HSV

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2
Q

Pap smear: numerous neuts with rare, multinucleated keratinocytes with”glassy” cytoplasm, no evidence of cerival intraepithelial neoplasia.

A

HSV

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3
Q

Not vesicular or ulcerative, but umbilicated.

A

Molluscum contagiosum

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4
Q

Five infecitons that present with ulcer

A

HSV, syphilis, chancroid, granuloma inguinale, LGV

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5
Q

Two infections that present with urethritis or cervitisis

A

gonorrhea, chlamydia

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6
Q
  • gummas, saddle node, deformity, saber skin
  • plasma cell infiltrates and endarteritis
  • Steiner silver stain used to id plasma cells.
A

Syphilis

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7
Q
  • *Vertical transmission during delivery (neonatal transmission = MORTALITY), possible latency in nerves later on.
  • blindness, encephalitis
  • increases HIV transmission
A

HSV

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8
Q

1) Multinucleation due to cell fusion and

2) viral replication has pushed chromatin to periphery

A

HSV

2=cowdry A

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9
Q

26 year old with dyspareunia for 2mo. 2cm swollen, tender mass on posterolateral-left labia. Culture positive for N. gonococus.

  • What labial structure is involved?
  • What potential complication if left untx?
A

Bartholin gland.

Complication - tuboovarian abscess.

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10
Q

HPV assoc with..

A

cervical dysplasia

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11
Q

DES assoc with…

A

Vaginal adenosis

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12
Q

Lichen sclerosis assoc with….

A

vaginal agglutination

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13
Q

Gonococcus and Chlamydia assoc with…

A

PID

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14
Q

yellow frothy discharge - most likely organism

A

Trichomonas Vaginalis

Strawberry cervix

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15
Q

stillbirth

A

listeria

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16
Q

Dyspareunia, red, crusted, maplike area on labia bilaterally. intraepithelial malignancy

A

extramammary paget disease

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17
Q

Dyspareunia, vulvar epidermis is thin, resembles “parchment”

A

lichen sclerosis

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18
Q

Slighty raised white lesions b/l on vulva. Biopsy: epidermal thickening with loss of maturation, increased mitosis and nuclear atypia, and surface koilocytes.

A

Classic type vulvar intraepithelial neoplasia (VIN)

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19
Q

**Koilocyte = what organism

A

HPV (classic VIN, condyloma (Low grade 6,11),
CIN (high grade))

dt E5

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20
Q

intraepithelial Ca, PAS, cytokeratin 7 - assoc with…

A

extramammary paget dz

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21
Q

differentiated VIN/TP53 - assoc with…

A

lichen sclerosis

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22
Q

sharply circumscribed nodule on the vulva. commonly of labia majora. ulcerative. B9 glandular “breast like” lesion - assoc with…

A

papillary hidradenoma

histo identical to intraductal papilloma of the breast

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23
Q
  1. Hyperkeratosis
  2. Thin epidermis
  3. Basal cell layer degeneration
  4. Sclerosis of superficial dermis
  5. Band like lymphocytic infiltrate in underlying dermis
A

Pathog histologic features of lichen sclerosis

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24
Q

Numerous squamous cells with nuclear enlargement, hyperchromasia, and “halos”, course chromatin granules

A

HPV

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25
Q

CIN1-4 - what is moderate v. moderate v. severe dyspasia? LSIL v. HSIL?

A

CIN1 = LSIL (mild dysplasia)
CIN2-4 = HSIL
all high grade HPV

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26
Q

Cervical biopsy: atypical cells in lower 1/3rd and koilocytes in upper 2/3

A

LSIL (CIN1)

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27
Q

Ki-67 proliferation marker is associated with…

28
Q

Cervical biopsy: atypical cells in in upper 2/3rd and koilocytes

29
Q

38 year old with AUB.
Day 10 of cycle when biopsy taken: polyploid fragments of endometrial tissue that display increase glands compared to stroma. No cytologic atypic, normal stroma present between glands.

A

Endometrial hyperplasia

**increase glands compared to stroma

30
Q

Conditions that increase risk of endometrial hyperplasia. Why?

A

Incresed estrogen dt OBESITY, menopause, granulosa cell tumors, PCOS, iatrogenic.

31
Q

Significant pt characteristic in determining cause of AUB

A

age (table 22-3)

32
Q

58 year old African American woman Endometrial biopsy reveals atypical malignant cells with high n/c ration, mitotic figures, hyperchromasia in background of endometrial atrophy. At hysterectomy, invasive poorly differentiated Ca with papillary architecture and identical cytologic features. Tumor cells strong ab to p53 - Most likely?

A

Type 2 = serous Ca

intraeritoneal spread

33
Q

Endometrial Cancer: type 2 v. 1 behavior

A

aggressive v. indolent behavior

34
Q

Endometrial Cancer: precursor to type 2 v. type 1

A

uterine atrophy v. uterine hyperplasia

35
Q

Endometrial Cancer: body type 2 v. 1

A

thin v. obese

36
Q

Endometrial Cancer: markers type 2 v. 1

A

p53 v. PTEN

37
Q

Endometrial Cancer: behavior of spread type 2 v. 1

A

Intraperitoneal and lymphatic v. only lymphatics

38
Q

Edometrium: Malignant stroma and malignant glands

A

MMMT (carcinomasarcoma) - bad outcome (heterologous = bone, mm, fat - not only sm mm of the uterus)

39
Q

Edometrium: Malignant stroma and B9 glands

A

Adenomsarcoma (low grade malignancy of endometrial stroma)

40
Q

Edometrium: Malignant stroma and no glands

A

endometrial stromal sarcoma

41
Q

What is this and what genetics: 44 year old obese woman with AUB. Endometrial biopsy shows no hyperplasia or malignancy. Tumors described as whorled and bulging tumor.

42
Q

What is this and what genetics: 44 year old obese woman with AUB. Endometrial biopsy shows more than 10 mitoses per 10 mitotic fields.

A

leiomyosarcoma

43
Q

What is this: 28 year old with **dysmenorrhea and **constipation. Monogamous, basal body temp increase in 2nd half of cycle. Pap and colonoscopy normal. Laparoscopy revel small paratubal cysts bilaterally and scattered **red-blue-brown nodules on tubes and ovaries bilaterally.

A

Endometriosis

Increased estrogen production by the stromal cell component.

44
Q

Cause of Infertility due to: Ovulation disorder due to testosterone

45
Q

Causes of Infertility due to: Uterine or cervical abnormalities could be caused by…

A

Didelphys, leiomyopa, polyps

46
Q

Causes of Infertility due to: fallopian tube damage/blockage

A

PID, endometriosis

47
Q

Causes of Infertility due to: Ovary tumor

A

Sertoli-Leydig Tumor (sterile, possibly heterologous)

48
Q

What is this and possible progression: 27 year old primigravida. Right ovarian mass has a wrinkled gray-white epidermal lining and contains hair.

A

Mature teratoma - 1% (dermoid cysts) undergo malignant transformation (to SCCa). Rare bilaterality.

49
Q

Met from utaneous primary

A

Mullerian and non mullerian

50
Q

elevated hCG

A

dysgerminoma, (germ cell and gestational) choriocarcionoma, complete and partial moles

51
Q

Overweight 55 year old female with increasing abdominal girth. CT=bl enlarged ovaries, omental involvement, mass @ cecum. Surgery shows extensive pseudomyxoma peritonei

A

Met from appendiceal primary. (cecum=appendix!)

52
Q

Associated with what tumor: Call-Exner bodies (Occasional follicle/gland like structures with acidophilic material)

A

Granulosa Cell Tumor

53
Q

Associated with what tumor: tumor with surface CILIA in ovaries

A

serous ovarian epithelial tumor

54
Q

Inhibin

A

granulosa cell tumor

55
Q

Syndrome: multiple cysts + hyperandrogenism + menstrual irregularities + chronic anovulation + decreased fertility

56
Q

Syndrome: B9 ovarian tumor (fibrothecoma), ascites, and hydrothorax on right side.

57
Q

B-hCG elevation. 4mo postpartum with no brest feeding. Hemorrhagic mass in vagina with histo of cyto- and syncytiotrophoblasts with minimal necrosis

A

(gestational) Choriocarcinoma. (metastatic to brain, bone, lungs, vagina, but good outcome!)

58
Q

villi and fetal parts

A

partial mole

59
Q

hydropic villi and trophoblast cells.

A

invasive mole

60
Q

All moles have what structures?

A

villous (grapelike)

61
Q

what chorioCa is fatal?

A

Germ cell ChorioCa

62
Q

Breast: Mass discharges purulent material from edge of aureola.

A

Squamous metaplasia of lactiferous ducts (smoking association)

63
Q

Breast: Tumor and dermal lymphatics assoc with what entity?

A

inflammatory subtype of breast cancer/peau d’ orange

64
Q

Breast: acid fast org in discharge assoc with what entity and infection?

A

granulomatous mastitis (TB)

65
Q

Breat: lymphocytic mastitis assoc with what dz?

66
Q

Basal like cancer

A

ER-, HER2- (triple negative)

no precursor, poorly differnetiated, HISPANICS, great response to chemo

Reproduction Two (12 decks)

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