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CIS Flashcards

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1
Q

24 year old F. Vesicles bilaterally on labia majora. A few around urethral meatus. Mild inguinal adenoapthy present. Most likely?

A

HSV

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2
Q

Pap smear: numerous neuts with rare, multinucleated keratinocytes with”glassy” cytoplasm, no evidence of cerival intraepithelial neoplasia.

A

HSV

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3
Q

Not vesicular or ulcerative, but umbilicated.

A

Molluscum contagiosum

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4
Q

Five infecitons that present with ulcer

A

HSV, syphilis, chancroid, granuloma inguinale, LGV

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5
Q

Two infections that present with urethritis or cervitisis

A

gonorrhea, chlamydia

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6
Q
  • gummas, saddle node, deformity, saber skin
  • plasma cell infiltrates and endarteritis
  • Steiner silver stain used to id plasma cells.
A

Syphilis

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7
Q
  • *Vertical transmission during delivery (neonatal transmission = MORTALITY), possible latency in nerves later on.
  • blindness, encephalitis
  • increases HIV transmission
A

HSV

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8
Q

1) Multinucleation due to cell fusion and

2) viral replication has pushed chromatin to periphery

A

HSV

2=cowdry A

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9
Q

26 year old with dyspareunia for 2mo. 2cm swollen, tender mass on posterolateral-left labia. Culture positive for N. gonococus.

  • What labial structure is involved?
  • What potential complication if left untx?
A

Bartholin gland.

Complication - tuboovarian abscess.

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10
Q

HPV assoc with..

A

cervical dysplasia

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11
Q

DES assoc with…

A

Vaginal adenosis

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12
Q

Lichen sclerosis assoc with….

A

vaginal agglutination

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13
Q

Gonococcus and Chlamydia assoc with…

A

PID

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14
Q

yellow frothy discharge - most likely organism

A

Trichomonas Vaginalis

Strawberry cervix

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15
Q

stillbirth

A

listeria

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16
Q

Dyspareunia, red, crusted, maplike area on labia bilaterally. intraepithelial malignancy

A

extramammary paget disease

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17
Q

Dyspareunia, vulvar epidermis is thin, resembles “parchment”

A

lichen sclerosis

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18
Q

Slighty raised white lesions b/l on vulva. Biopsy: epidermal thickening with loss of maturation, increased mitosis and nuclear atypia, and surface koilocytes.

A

Classic type vulvar intraepithelial neoplasia (VIN)

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19
Q

**Koilocyte = what organism

A

HPV (classic VIN, condyloma (Low grade 6,11),
CIN (high grade))

dt E5

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20
Q

intraepithelial Ca, PAS, cytokeratin 7 - assoc with…

A

extramammary paget dz

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21
Q

differentiated VIN/TP53 - assoc with…

A

lichen sclerosis

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22
Q

sharply circumscribed nodule on the vulva. commonly of labia majora. ulcerative. B9 glandular “breast like” lesion - assoc with…

A

papillary hidradenoma

histo identical to intraductal papilloma of the breast

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23
Q
  1. Hyperkeratosis
  2. Thin epidermis
  3. Basal cell layer degeneration
  4. Sclerosis of superficial dermis
  5. Band like lymphocytic infiltrate in underlying dermis
A

Pathog histologic features of lichen sclerosis

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24
Q

Numerous squamous cells with nuclear enlargement, hyperchromasia, and “halos”, course chromatin granules

A

HPV

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25
CIN1-4 - what is moderate v. moderate v. severe dyspasia? LSIL v. HSIL?
CIN1 = LSIL (mild dysplasia) CIN2-4 = HSIL all high grade HPV
26
Cervical biopsy: atypical cells in lower 1/3rd and koilocytes in upper 2/3
LSIL (CIN1)
27
Ki-67 proliferation marker is associated with...
HSIL
28
Cervical biopsy: atypical cells in in upper 2/3rd and koilocytes
HSIL
29
38 year old with AUB. Day 10 of cycle when biopsy taken: polyploid fragments of endometrial tissue that display increase glands compared to stroma. No cytologic atypic, normal stroma present between glands.
Endometrial hyperplasia | **increase glands compared to stroma
30
Conditions that increase risk of endometrial hyperplasia. Why?
Incresed estrogen dt OBESITY, menopause, granulosa cell tumors, PCOS, iatrogenic.
31
Significant pt characteristic in determining cause of AUB
age (table 22-3)
32
58 year old African American woman Endometrial biopsy reveals atypical malignant cells with high n/c ration, mitotic figures, hyperchromasia in background of endometrial atrophy. At hysterectomy, invasive poorly differentiated Ca with papillary architecture and identical cytologic features. Tumor cells strong ab to p53 - Most likely?
Type 2 = serous Ca intraeritoneal spread
33
Endometrial Cancer: type 2 v. 1 behavior
aggressive v. indolent behavior
34
Endometrial Cancer: precursor to type 2 v. type 1
uterine atrophy v. uterine hyperplasia
35
Endometrial Cancer: body type 2 v. 1
thin v. obese
36
Endometrial Cancer: markers type 2 v. 1
p53 v. PTEN
37
Endometrial Cancer: behavior of spread type 2 v. 1
Intraperitoneal and lymphatic v. only lymphatics
38
Edometrium: Malignant stroma and malignant glands
MMMT (carcinomasarcoma) - bad outcome (heterologous = bone, mm, fat - not only sm mm of the uterus)
39
Edometrium: Malignant stroma and B9 glands
Adenomsarcoma (low grade malignancy of endometrial stroma)
40
Edometrium: Malignant stroma and no glands
endometrial stromal sarcoma
41
What is this and what genetics: 44 year old obese woman with AUB. Endometrial biopsy shows no hyperplasia or malignancy. Tumors described as whorled and bulging tumor.
Leiomyoma
42
What is this and what genetics: 44 year old obese woman with AUB. Endometrial biopsy shows more than 10 mitoses per 10 mitotic fields.
leiomyosarcoma
43
What is this: 28 year old with **dysmenorrhea and **constipation. Monogamous, basal body temp increase in 2nd half of cycle. Pap and colonoscopy normal. Laparoscopy revel small paratubal cysts bilaterally and scattered **red-blue-brown nodules on tubes and ovaries bilaterally.
Endometriosis Increased estrogen production by the stromal cell component.
44
Cause of Infertility due to: Ovulation disorder due to testosterone
PCOS
45
Causes of Infertility due to: Uterine or cervical abnormalities could be caused by...
Didelphys, leiomyopa, polyps
46
Causes of Infertility due to: fallopian tube damage/blockage
PID, endometriosis
47
Causes of Infertility due to: Ovary tumor
Sertoli-Leydig Tumor (sterile, possibly heterologous)
48
What is this and possible progression: 27 year old primigravida. Right ovarian mass has a wrinkled gray-white epidermal lining and contains hair.
Mature teratoma - 1% (dermoid cysts) undergo malignant transformation (to SCCa). Rare bilaterality.
49
Met from utaneous primary
Mullerian and non mullerian
50
elevated hCG
dysgerminoma, (germ cell and gestational) choriocarcionoma, complete and partial moles
51
Overweight 55 year old female with increasing abdominal girth. CT=bl enlarged ovaries, omental involvement, mass @ cecum. Surgery shows extensive pseudomyxoma peritonei
Met from appendiceal primary. (cecum=appendix!)
52
Associated with what tumor: Call-Exner bodies (Occasional follicle/gland like structures with acidophilic material)
Granulosa Cell Tumor
53
Associated with what tumor: tumor with surface CILIA in ovaries
serous ovarian epithelial tumor
54
Inhibin
granulosa cell tumor
55
Syndrome: multiple cysts + hyperandrogenism + menstrual irregularities + chronic anovulation + decreased fertility
PCOS
56
Syndrome: B9 ovarian tumor (fibrothecoma), ascites, and hydrothorax on right side.
Meigs
57
B-hCG elevation. 4mo postpartum with no brest feeding. Hemorrhagic mass in vagina with histo of cyto- and syncytiotrophoblasts with minimal necrosis
(gestational) Choriocarcinoma. (metastatic to brain, bone, lungs, vagina, but good outcome!)
58
villi and fetal parts
partial mole
59
hydropic villi and trophoblast cells.
invasive mole
60
All moles have what structures?
villous (grapelike)
61
what chorioCa is fatal?
Germ cell ChorioCa
62
Breast: Mass discharges purulent material from edge of aureola.
Squamous metaplasia of lactiferous ducts (smoking association)
63
Breast: Tumor and dermal lymphatics assoc with what entity?
inflammatory subtype of breast cancer/peau d' orange
64
Breast: acid fast org in discharge assoc with what entity and infection?
granulomatous mastitis (TB)
65
Breat: lymphocytic mastitis assoc with what dz?
DM2
66
Basal like cancer
ER-, HER2- (triple negative) | no precursor, poorly differnetiated, HISPANICS, great response to chemo

Reproduction Two (12 decks)

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