Breast molecular Flashcards
BRCA1
- *familial breast and ovarian Ca
- Fallopian tube, prostate, pancreatic cancer
BRCA2
- *Familial breast and ovarian cancer
- male breast cancer
- prostate, pancreas, stomach, melanoma, GB, bile duct, pharynx
TP53
- Li Fraumeni
- Brain tumors
- sarcoma, leukemia, adrenocortical Ca, others
CHEK2
Prostate, thyroid, kidney, colon
BRCA1 v. BRCA 2 v. TP53 - risk of breast cancer by 70 years
BRCA1: 40-90%
BRCA2: 30-90%
TP53: >90%
What gene mutation results in breast Ca that are commonly poorly differentiated and triple negative (basal-like) and have TP53 mutations?
BRCA1
What gene is the most commonly mutated gene in sporadic breast cancer? Half are ER__ and HER2__
TP53.
Half are ER(-) and HER2(+)
What may mutation may increase risk for breast cancer after radiation exposure? 70-80% are ER__
CHEK2, ER(+)
What molecular subtype of invasive breast cancer typically involves older women and men?
Low proliferation ER(+) HER2(-)
What molecular subtype of invasive breast cancer typically involves BRCA2 mutation carriers?
High proliferation ER(+) HER2(-)
What molecular subtype of invasive breast cancer typically involves young women, non white women, TP53 mutation carriers (ER+)
HER2+ (ER+/-)
What molecular subtype of invasive breast cancer typically involves young women, BRCA1 mutation carriers, BLACKS and HISPANICS.
ER(-) and HER2(-)
Metastatic pattern of High and Low Proliferation ER+ HER2-
Bone (>visceral or brain)
Metastatic pattern of HER2+
Bone, **visceral, **brain
Metastatic pattern of ER- HER2-
Bone, viscera, brain
