Circulatory system Flashcards
Tunica intima
INNER
Endothelium (epithelial cells)
Reduce friction
Tunica media
MIDDLE
Muscle cells
Alter vessel diameter
Tunica externa
OUTER
Connective tissue
Protection and anchor to surrounding tissue
Arteries
Carry blood AWAY from the heart
Elastic arteries
Conducting vessel
High elastin content
Muscular arteries
Distributing vessels
Thick tunica media
Change diameter to control blood flow
Arterioles
Resistance vessels
Thin walls, mainly TM
Control resistance to blood flow and flow into capillaries
Capillaires
Connect arteries and veins
EXCHANGE VESSELS - site of nutrient exchange
Continuous capillaries
Endothelial cells
Gaps in endothelial cells = intercellular clefts
Fluid and sml solutes enter via IC clefts
Fenestrated capillaries
Endothelial cells
Pores = fenestrations increase permeability
Larger volumes of fluid and solutes can enter/exit
Sinusoidal capillaries
Endothelial cells
Large gaps = sinusoids = leaky
Larges molecules to pass through
Terminal arteriole
Supplies capillary bed with O2 blood
Terminal venule
Drains deO2 blood from capillary bed
Veins
CAPACITANCE VESSLES
Tunica intima forms valves
Thick tunica externa
60% blood volume reservoir in veins
Blood flow
The VOLUME of blood flowing through a vessel organ or the entire circulation in a given time period
Blood pressure
The FORCE exerted on a vessel wall by the blood in that vessel
Resistance
Opposition to blood flow
Friction
BF =
P/R
PP =
Difference between systolic and diastolic pressure
S - D
MAP =
D + 1/3(PP)
In which vessel does the biggest drop in BP occur
Capillaries
High P can damage thin walls
Permeable, so low P required for fluid exchange
How do veins provide adequate venous return
Valves Muscle pump Respiratory pump Pulsation Venoconstriction
Functions of autoregulation of BP
Metabolic control
Myogenetic (muscle) control
Functions of neural regulation of BP
Cardioinhibitory: parasymp to SA and AV nodes to dec HR and CO
Cardioacceletory: symp to SA and AV nodes to inc HR and CO AND symp to ventricular myocardium to inc force (SV) and CO
Vasomotor: symp to change vessel diameter **Baroreceptor reflex
Functions of renal mechansms
Direct mechanism: rate of urine formation
Indirect mechanism: RAAS
RAAS
Dec Art P Inhibits baroreceptors Inc RENIN release. Stimulates: - Angiotensinogen - Angiotensin I (ACE) - ANGIOTENSIN II:
- Stims inc aldosterone release to inc Na+ (and water) reabsorption
- Inc ADH release == inc water reabsorption
- Inc thirst == inc water intake
- Vasocontriction == inc peripheral resistance
==> Inc MAP
Baroreceptor reflex for inc BP
Barorecs stimulates
Inc parasymp and dec symp to heart = dec HR, SV and CO
Dec symp to tunica media = vasodilation = dec R
=> Dec CO and R == dec BP to homeostatic range
Baroreceptor reflex for dec BP
Barorecs inhibited
Dec parasymp and inc symp to heart = inc HR, SV and CO
Inc symp to tunica media = vasoconstriction = inc R
=> Inc CO and R == inc BP to homeostatic range
Hormones that inc BP
A
NA
Angiotensin II
Hormones that dec BP
Atrial natriuetic peptide (ANP)