circulation

Question 1

origin of platelets in terms of anatomical site, precursor cell type and method of production

Question 2

explain role of platelets in forming a thrombus in relation to trauma or tissue damage

Question 3

explain main site of production of certain key clotting factors

Question 4

discuss MOA of certain key clotting functions , particularly production of fibrin (from fibrinogen) in producing clots and thrombi

Question 5

describe difference between clot and thrombus formation

Question 6

describe Virchow’s triad - give on examples of each situation

Question 7

ischaemia

Question 8

hypoxia

Question 9

anoxia

Question 10

necrosis

Question 11

infarction

Question 12

why does ischaemia lead to hypoxia

Question 13

consequences of ischaemia causing reversible problems versus ischaemia resulting in localised death of tissues (infarction)

Question 14

understand difference between tissues that can withstand ischaemia for extended periods and tissues that are sensitive to even short-term ischaemia

Question 15

embolism - consequences and example

Question 16

circulatory shock

Question 17

pathogenesis of circulatory shock of 3 major types

Question 18

explain physiological mechanism which try to maintain BP in shock

Question 19

discuss organ damage, which occurs in shock, with reference to 2 main examples