chronic myeloid leukaemia

Question 1

what is the definition of Chronic myeloid leukaemia?

Answer 1

1. cells only mature partially

2. progressive accumulation of mature myeloid cells in bone marrow and blood

Question 2

which cells proliferate?

Answer 2

1. unregulated myeloid growth
2. proliferation of granulocytes

• neutrophils
• eisenophils
• basophils

Question 3

what is the genetic pathology of CML?

Answer 3

1. chromosomal translocation - philidelphia chromosome

2. BCR-Abl fusion gene

Question 4

Clinical features

Answer 4

1. splenomegaly
2. bone pain
3. mainly assymptomatic

Question 5

what is the median age it presents?

Answer 5

50 - 60 years

Question 6

how is CML diagnosed?

Answer 6

1. FBC
   - high basophils/eisenophils
2. Bone marrow biopsy
   - chromosomal transolation
   - phiidephia chromosome

Question 7

Mx

Answer 7

1. tyrosine kinase inhibitor

2. imantinib