acute myeloid leukaemia

Question 1

What is the definition of AML?

Answer 1

rapid growth of unmatured myeloid blood cells (myelopblast)

build up in bone marrow and blood

interfere with normal blood cell prodcution

Question 2

how does AML porgress?

Answer 2

progresses rapidly and is fatal within weeks

Question 3

What do myeloid blast cells develop into?

Answer 3

1. Red blood cells
2. platelets
3. Neutrophils/basophils/eisenophils

Question 4

Name 3 clinical signs?

Answer 4

1. splenomegaly
2. swollen gums
3. lymphadenopathy

Question 5

Name clinical symptoms

Answer 5

1. frequent infections
2. anaemia
3. bruising and bleeding
4. bone pain

Question 6

name 3 risk factors for AML?

Answer 6

1. exposure to radiation
2. alkylating chemotherapy
3. Down’s syndrome

Question 7

What is a genetic risk factor for AML development?

Answer 7

Down’s syndrome

Question 8

How can AML be diagnosed?

Answer 8

1. Full blood count
   - lekocytosis
2. Blood smear
   - leukaemic blast cells
3. Bone marrow biopsy

Question 9

Tx

Answer 9

1. chemotherapy

2. stem cell transplant

Question 10

what age does AML present?

Answer 10

70 +

Question 11

Prognosis of AML?

Answer 11

poor prognosis