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IHO Week 4 > Chronic Lymphocytic Leukemia - Krafts > Flashcards

Chronic Lymphocytic Leukemia - Krafts Flashcards

1
Q

What is CLL?

A

Chronic Lymphocytic Leukemia

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2
Q

What are the characteristics of CLL?

A

ONLY in Adults (>40)
Long course
Indolent, but incurable

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3
Q

What is the definition of CLL?

A

Malignant proliferation of lymphocytes in blood and bone marrow

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4
Q

What are the cellular characteristics of CLL?

A 
aka Small Lymphocytic Lymphoma
Small, mature lymphocytes
B-cell with CD19, CD20, CD21, but also has CD5
Long, but inexorable course
Negative for TdT
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5
Q

What are the clinical findings of CLL?

A

Asymptomatic at first

Organ infiltration later

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6
Q

What are the laboratory findings in CLL?

A

HIGH WBC

Hypogammaglobulinemia

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7
Q

What is the pathophysiology of CLL?

A

Bcl-2 gene rearrangement

*normally, Bcl-2 prevents apoptosis

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8
Q

What is the treatment of CLL?

A

Conservative

Reduce organomegaly and risk for infections

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9
Q

What is the prognosis of CLL?

A

Normal platelet count, WBC count
Adenopathy
Bone Marrow pattern
Chromosomal abnormalities

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10
Q

What is the cause of death in a patient with CLL?

A

Infection (survival is about 9 years)

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11
Q

What are the characteristics of hairy cell leukemia?

A

Hairy cells
Splenomegaly without lymphadenopathy
Pancytopenia
TRAP+

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12
Q

What is pancytopenia?

A

Low RBC, Low WBC, Low Platelets

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13
Q

What are the clinical findings of hairy cell leukemia?

A

Occurs in adults (>40)

Male:Female ratio: 5:1

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14
Q

What is the cytochemistry stain used to diagnose hairy cell leukemia?

A

TRAP+

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15
Q

What is the immunophenotype to diagnose hairy cell leukemia?

A

B-cells with CD25 and CD11c

Negative for CD5

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16
Q

What is the treatment for hairy cell leukemia?

A

Chemotherapy - one blast of high dose chemo

17
Q

What is the prognosis for hairy cell leukemia?

18
Q

What are the laboratory findings in hairy cell leukemia?

A

Usually Pancytopenia

Always Monocytopenia

19
Q

What are the characteristics of Prolymphocytic Leukemia?

A

Prolymphocytes (Dense Chromatin)
Splenomegaly without lymphadenopathy
Aggressive, but rare

20
Q

What are the laboratory findings of Prolymphocytic Leukemia?

A

HIGH WBC
Low Hemoglobin
Low Platelet Count

21
Q

What are the characteristics of large granulated lymphocyte leukemia?

A

Large Granulated Lymphocytes
T-cell
Neutropenia

22
Q

What are the clinical findings of large granulated lymphocyte leukemia?

A

Infections from neutropenia

LONG survival

23
Q

What is the immunophenotype of large granulated lymphocyte leukemia?

24
Q

What are the laboratory findings of large granulated lymphocyte leukemia?

A

Elevated WBC

Neutropenia

IHO Week 4 (15 decks)

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