Chronic Inflammation- Clinical Questions

Question 1

What microscopic features are seen within the joints of someone with rheumatoid arthritis?

Answer 1

Chronic inflammatory features:

Panos,hyperplasia, fibrosis, erosion of articular cartilage

Question 2

Which 3 cell types are most commonly seen in chronic inflammatory infiltrate? What are their functions?

Answer 2

Lymphocytes- B cells differentiate into antibiotics, T control and produce some cytotoxins

Macrophages- phagocytosis, synthesis of cytokines, antigen presenting, cellular control

Plasma cells-differentiate B cells-producing a single type of antibody (v specific)

Question 3

In what ethnicity is sarcoidosis more prevelant?

Answer 3

Afro-caribbean

Question 4

How might you distinguish between sarcoidosis and TB?

Answer 4

Tests:
PCR- look for DNA
Culture tissue- identify microbacteria
Biopsy of lymph node

Question 5

What 2 things will be high in the blood test of someone with sarcoidosis?

Answer 5

Ca2+,ACE