Chronic Inflammation And Wound Healing Flashcards
What are the 4 phases of wound healing
Haemostasis
Inflammation
Proliferation
Remodelling
What do neutrophils do
Remove bacteria and foreign material
Phagocytosis and enzyme secretion
Short lived
What do macrophages do
Recruited from blood monocytes
Proliferate locally
Phagocytosis of remaining debris
What do fibroblasts do
Proliferate, migrate and become myofibroblast
Synthesis of matrix proteins e.g. collagen
What do keratinocytes do
Proliferation and migration of cells over wound bed
Re epithelialisation
Angiogenesis - new blood vessel formation
What type of collagen happens during remodelling
Type III collagen replaced by bundles of type I
What percentage is the wound strength after 7-10 days
10% strength
What percentage is the wound strength after 2-3 months
70-80%
What is required for remodelling
Proteases (collagenases)
What key cell is the early inflammation response
Neutrophil
What is primary intention
Wound edges are apposed and held in place by mechanical means (sutures)
What is secondary intention
Wound left open edges come together naturally by granulation and contraction
Larger tissue loss more likely to scar
What are the 5 stages of bone healing
Heamatoma
Inflammation
Callus formation
Granulation tissue
Remodelling
