Chronic Inflammation Flashcards
What does both repair and organisation and chronic inflammation lead to?
Fibrosis
What factors favour resolution?
Minimal cell death and tissue damage
Occurrence in an organ or tissue with regenerative capacity
Rapid destruction of casual agent
Rapid removal of fluid and debris by good local vascular damage
What is organisation?
Replacement of destroyed tissue by granulation tissue
What factors favour organisation?
Large amounts of fibrin
Substantial necrosis
Exudate and debris cannot be removed or discharges
What are classic signs of the body moving into chronic inflammation?
Development of capillary loops and macrophages
What is redness caused by in a burn?
Outgrowth of capillaries
What is the inflammatory exudate replaced with when moving into organisation?
Capillaries
Macrophages
Fibroblasts
Collagen
What regulates organisation?
TNF
Epidermal Growth Factor
FGF
What is a primary chronic inflammation?
A chronic response that did not develop from an acute inflammatory reponse
How can chronic inflammation develop?
Primary
Progression from acute inflammation
Recurrent episodes of acute inflammation
What are the 6 origins of primary chronic inflammation?
Resistance of infective agent to phagocytosis and intracellular killing
Foreign body reactions to endogenous materials
Foreign body reactions to exogenous materials
Autoimmune diseases
Unknown aetiology
Primary granulomatous diseases
Example of a disease that has resistance of infective agent to phagocytosis and intracellular killing
TB
Leprosy
Example of a disease that is caused by a foreign body reaction’s to endogenous materials
Chronic tophaceous gout
Example of a disease that is caused by a foreign body reaction’s to exogenous materials
Asbestos
Example of chronic inflammatory disease caused by an autoimmune reaction
Rheumatoid arthritis