Chromosomal Abnormalities and the diseases they cause.

Question 1

Philadelphia chromosome causes what kind of leukemia?

Answer 1

t(9;22) -> Found in CML and subset of ALL

Question 2

These chromosome mutations, t(15;17)(q22;q12) are associated with what kind of leukemia and condition?

Answer 2

Acute Promyelocytic Leukemia (APL - M3) & DIC (due to auer rods I think)

Question 3

What chromosomes are associated with Acute myeloid leukemia (AML)?

Answer 3

c. t(8;21)(q22;q22): and (16)(p13.1p22)

Question 4

What chromosome mutation is associated with mantle cell lymphoma?

Answer 4

t(11;14)

Question 5

What chromosome mutation are associated with follicular lymphoma?

Answer 5

t(14;18)

Question 6

What chromosome mutations are associated with Burkitt lymphoma?

Answer 6

t(8;14), t(2;8), t(8;22)