CHROMATOGRAPHY

Question 1

a process in which a solution of a mixture containing inert materials, drug principles, and impurities is separated into its components while moving through a bed of fixed porous solid having different and reversible affinities for the substances being spearated

Answer 1

CHROMATOGRAPHY

Question 2

it is derived from the method’s original use in the separation of colored compound on a suitable absorbent.

Answer 2

CHROMATOGRAPHY

Question 3

useful as a means of separating and purifying complex and closely related chemical substances which are difficult, if not impossible, to separate by classical methods based on differences in solubility and volatility.

Answer 3

CHROMATOGRAPHY

Question 4

Basic principles upon which chromatographic separation depends are:

Answer 4

ADSORPTION
PARTITION
ION EXHANGE
MOLECULAR EXCLUSION

Question 5

The techniques employed in holding the porous solid, the procedure are:

Answer 5

COLUMN CHROMATOGRAPHY
PAPER CHROMATOGRAPHY
THIN-LAYER CHROMATOGRAPHY

Question 6

Procedure commonly used to developed chromatograms

Answer 6

ELUTION CHROMATOGRAPHY

Question 7

The column is washed with suitable solvents, referred to as?

Answer 7

ELUANTS

Question 8

It brings about the separation of a mixture through a competitive process in which the molecules of the mobile phase compete with analyte molecules for polar absorption sites on the adsorbent.

Answer 8

ADSORBTION CHROMATOGRAPHY

Question 9

Chromatographic process when mobile phase is a liquid.

Answer 9

LIUID-SOLID CHROMATOGRAPHY

Question 10

the mobile and the stationary phases are liquids, is referred to as liquid-liquid chromatography (LLC)

Answer 10

PARTITION CHROMATOGRAPHY

Question 11

Based on the techniques employed in holding the porous solid, the procedure is called?

Answer 11

COLUMN CHROMATOGRAPHY
PAPER CHROMATOGRAPHY
THIN-LAYER CHROMATOGRAPHY

Question 12

The material placed in a column to absorb drug is referred to as the?

Answer 12

ADSORBENT

Question 13

The drug particles are quantitatively removed from the solution by ____ in a narrow band at the top of the column.

Answer 13

ADSORPTION

Question 14

the assay of this requires prior separation using column adsorption chromatography.

Answer 14

ACETAMINOPHEN ELIXIR U.S.P

Question 15

The length of the chromatographic column is composed of many small, identical cells called?

Answer 15

THEORETICAL PLATED

Question 16

The lower phase is called the?

Answer 16

STATIONARY PHASE

Question 17

The upper phase is called?

Answer 17

MOBILE PHASE

Question 18

Each volume of upper phase eluting from the column is called?

Answer 18

PLATE VOLUME