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Pharmacology Autonomic drugs > Cholinomimetics Indirect > Flashcards

Cholinomimetics Indirect Flashcards

1
Q

pyridostigmine

mech

A

4a amine- doesnt cross BBB

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2
Q

pyridostigmine

tx

A

myasthenia gravis

reverse neuromuscular blockade

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3
Q

neostigmine

mech

A

4a amine- doesnt cross BBB

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4
Q

neostigmine

Tx

A

Myasthenia gravis
reverse neuromuscular blockade (competitive blockers like curare)
post op urinary retention/ paralytic ileus
lowers IOP

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5
Q

Endophobium

mech

A

4a amine- doesnt cross BBB

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6
Q

endrophobium

tx

A

used to diagnose MG

  • give endrophobium to see if muscle weakness improves
  • if muscle weakness doesnt improve– cholinergic crisis

used to evaluate tx of MG

  • if muscle weakness improves- dose is too low
  • if muscle weakness increases- dose is too high– due to depolarizing blockade
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7
Q

physostigmine

mech

A

Crosses BBB*****

direct agonist effects at nicotinic receptors

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8
Q

physositgmine

tx

A

DRUG OF CHOICE FOR ANTICHOLINERGIC POISONING (AKA ATROPINE OVERDOSE)

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9
Q

ambenobium

tx

A

Myasthenia Gravis

4a amine- doesn’t cross BBB

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10
Q

Carbaryl

tx

A

used as insecticide

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11
Q

what drugs are used to Tx Alzheimers

A

Galantamine
Rivastigmine
Donepezil

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12
Q

Galantamine

mech + tx

A

AchE inhibitor

Tx Alzheimers

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13
Q

Rivastigmine

mech + tx

A

AchE inhibitor

Tx Alzheimers AND Parkinsons

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14
Q

Dopenezil

mech + tx

A

reversible anticholinesterase with a better selectivity for AchE (better than the other inhibitors)

Tx Alzheimers

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15
Q

what drugs are 4a amines

A

pyridostigmine
neostigmine
endrophobium
( ambenobium )

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16
Q

what drugs are irreversible cholinesterase inhibitors

A

Echothiophate (phospholine)
Thiophosphate insectisides [Malathion + parathion ]
Nerve Agents [Sarin, Soman, Tabun Vx]

17
Q

Ectothiophate (phospholine)

mech + tx

A

irreversible
low lipid solubility (no CNS involvement)
Tx glaucoma

18
Q

Malathion + Parathion

mech + Tx

A

irreversible
thiophosphate insecticides

Malathion is converted into non toxic metabolites by birds and mammals

parathion isnt- more dangerous

19
Q

Nerve agents

examples and mech

A

Sarin, Soman, Tabum, Vx

extremely strong irreversible cholinesterase inhibitors, much greater intrinsic toxicity than the thiophosphate insecticides

act on Nicotinic and muscarinic receptors to produce (DUMBBELS and MATCH)

20
Q

Nerve agents effect on CNS

A

irritability, guiddiness, lethargy, amnesia, coma seizures and RESPIRATORY DEPRESSION ( cause of death)

21
Q

Tx for Nerve agents

effect of pyridostigmine??

A

Pralidoxime before aging process occurs
Atropine (anticholinesterase inhibitor)

pyridostigmine ( used prophillactically for people that have increased risk of exposure – since it is a reversible AchE inhibitor it can block the effect of nerve agents and it gives exposed people more time to be tx with pralidoxime and atropine)

Pharmacology Autonomic drugs (4 decks)

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