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Pharmacology Autonomic drugs > Adrenergic Agonists > Flashcards

Adrenergic Agonists Flashcards

1
Q

Selective A1 agonists

A

Phenylephrine
Midrodine
Visine

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2
Q

A2 agonists

A

Clonidine
Apraclonidine
Brimonidine
Guafanicine

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3
Q

B1 agonist

A

Dobutamine

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4
Q

B2 agonists

A

Albuterol
Formoterol
Metaproterenol
Salmeterenol

Terbutaline

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5
Q

B3 agonists

A

Mirabegron

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6
Q

Indirect sympathomimetics

A 
Amphetamine
Cocaine
Ritalin
Tyramine
Ephedrine/ pseudophedine
Adipex
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7
Q

Phenylephrine

Mech

A

A1

Inc MAP 
Inc Sys and Dias
Causes reflex bradycardia
Mydriasis
Vasoconstriction of nasal cavities
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8
Q

Phenylephrine

tx

A

Nasal congestion
Opthalmic- dilate eye
V tach - due to reflex bradycardia

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9
Q

Midrodine
mech
Tx

A

A1

Tx postural hypotension (Inc BP)

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10
Q

Visine

tx

A

A1

Nasal congestion
Red eyes (vasoconstriction)
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11
Q

Clonidine
Mech

Tx

A

A2
Inhibits sympatetic outflow from CNS

Tx- HTN
Tourettes
ADHD
Reduces effects of withdrawal

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12
Q

Guanfancine

A

A2

Same mechanism and tx as clonidine

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13
Q

Apraclonidine
Mech
Tx

A

A2

Dec IOP (via reduction in aqueous humor)

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14
Q

Brimonidine
Mech
Tx

A

A2

Dec IOP (reduction of aqueous humor)

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15
Q

Dobutamine
Mech
Tx

A

B1

Inc HR and contractility 
Tx HF (hypovolemic) AND SHOCK
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16
Q

Albuterol
Metraproterenol
Terbutaline

Mech
Tx

A

B2 (SHORT ACTING)

Bronchodilation- immediate effect (athsma)
Prevent preterm labor

17
Q

Salmeterol
Formoterol

Mech
Tx

A

B2 (long acting)

Used for control of athsma etc

18
Q

Mirabegron
Mech
Tx

A

B3

Used to tx urinary urgency
Relax detrussor to reduce voiding, less side effects bc its selective for B3

19
Q

Epinephrine

Low dose effects

A

B > A (at low doses beta effects are more predominant)

Bronchodilation
Vasodilation
Inc HR and contractility

20
Q 
Epinephrine 
High dose (like rapid IV)
A

Alpha effects predominate

Vasoconstriction (Inc SVR) 
Inc Systolic (a1) more than decrease diastolic (b2 effect)
Inc in PP
21
Q

Epinephrine

Slow infusion

A

Local vasoconstriction

Moderate inc in syst but MAP doesnt change

22
Q

Epinephrine is drug of choice for

A

Anaphylactic shock

  • bronchodilation b2
  • counteract vasodilation a1
  • improve blood flow B1
23
Q

Norepinephrine

Mech

A

A» b1

Inc MAP, inc SVR
Inc Sys/ dias
Reflex bradycardia
Inc contractility

24
Q

Norepinephrine

Tx

A

Shock

25
Q

Isoproterenol

Mech

A

B1=b2

Inc HR and contractility
Vasodilation ( dec MAP and SVR
Dec Systolic
Increase PP difference)

26
Q

Dopamine
D1 receptor
Mechanism effect

A

D1 inc cAMP
vasodilation of renal mesenteric and celiac
Increase in GFR!

Low dose: D1
Med dose: B1
High dose: A1

27
Q

Dopamine

D2 receptor effect

A

Modulates CNS neurotransmitter release (inhibits epi)

28
Q

Dopamine

Tx

A

CHF

cardiogenic shock, septic shock

29
Q

Fenoldopam

Tx

A

D1

Decrease BP in severe hypertension by dilating renal arteries

30
Q

Amphetamine

Mechanism

A

Indirect sympathomimetic
Increase release of D and NE
- by increasing vesicular displacement of NE nd D
- by reversing transport via TAAR (so instead of taking up dopamine it releases it) causing an increase of non vesicular release of Neuro transmitter

31
Q

Amphetamines
Tx?

Dosage effect

A

Used to improve cognitive function
Low dose: mild alert improved attention
Med dose: elevation of mood euphoria
High dose: psychotic behavior

(Tunes in prefrontal cortex but can also stimulate pleasure center so potential for addiction)

32
Q

Ritalin (methylphendinate)
Mech
Tx

A

Blocks reuptake of NE and D by inhibiting DAT NET
(but there is no reverse transport like in amphetamines)

Used in ADHD for lil kids

33
Q

Cocaine
Mech

Effects

A

Blocks reuptake of D Ne By inhibiting DAT and NET
Leading to excess dopamine in pleasure centers of brain

HTN tachy mydriasis
Convulsions hemorrage MI

34
Q

Tyramine

Mech

A

Byproduct of tyrosine metabolism (found in cheese and wine)
Indirect acting sympathomimetic
CONTRAINDICATED WITH MAOIs bc it can SEVERELY INCREASE NE —- LEADING TO HYPERTENSIVE CRISIS

35
Q

Ephedrine
Mech
Tx

A

Inc BP and CO

Also nasal congestion

36
Q

Pseudopherine

A

Cold decongestant

37
Q

Adipex

A

Inc NE and D to tx obesity

Short lived bc build tolerance

38
Q

CONTRAINDICATIONS for indirect

A

Use OF MAOIs
Can lead to xs NE
which can cause hypertensive crisis

39
Q

Complications of Adrenergic agonists

A

Increase of cardiac work—- ischemia and failure

Bad for old people with CAD

Pharmacology Autonomic drugs (4 decks)

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