Cholinomimetics Direct Flashcards
Ach (Miochol)
tx
miosis ocular surgery
reduce post operative IOP
Ach (miochol)
test
SWEAT SPOT TEST
used to test for autonomic neuropathy in diabetic patients
Bethanechol
mechanism
M
increases GI tone and motility
only one given systemically
bethanechol
tx
acute post op and NON obstructive urinary retention
carbachol
mech
Nicotinic* activity
increased activity in ganglia, skeletal muscle and adrenal (limited to opthalmic injections)
carbachol
tx
miosis ocular surgery
reduce post operative IOP
muscarine
tx
no clinical uses
found from amanita muscaria
cevimeline
mech and tx
M1 and M3
tx Sjogrens dry mouth
pilocarpine
mech
tertiary amine, crosses BBB*
active in eye– decrease IOP by contraction of ciliary muscle
also causes miosis of eye
pilocarpine
tx
angle closure glaucoma via reduction of IOP
close angle glaucoma via miosis of eye– opening angle of interior chamber of eye
Sjogrens– increased salivation
nicotine
mech
activates and inhibits nicotinic Ach receptors via mimicking blockade — flaccid paralysis of muscles
(acts on autonomic ganglia,adrenal, cns and muscle
nicotine
tx
smoking cessation
varenecline
mech
PARTIAL nicotinic agonist
stimulates receptor in brain and block actions of nicotine
Varenecline
tx
smoking cessation
which Direct cholinomimetics are Choline Esters
Bethacholine
carbachol
methacholine
Ach (miochol)
(remember these dont cross the BBB!! since they all contain permanently charged ammonium groups)
