Cholinergics vs anticholinergics Flashcards

1
Q

Bethanechol

A

Cholinergic

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2
Q

Carbachol

A

Cholinergic

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3
Q

Pilocarpine

A

Cholinergic used in glaucoma

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4
Q

Methacholine

A

Cholinergic used to induce a bronchial challenge test

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5
Q

Neostigmine

A

Cholinergic

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6
Q

Pyridostigmine

A

Cholinergic used in myasthenia gravis

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7
Q

Edrophonium

A

Cholinergic

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8
Q

Physostigmine

A

Cholinergic used in glaucoma and atropine overdoses

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9
Q

Donepezil

A

Cholinergic used to improve Alzheimer dementia

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10
Q

Rivastigmine

A

Cholinergic

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11
Q

Galantamine

A

Cholinergic

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12
Q

Atropine

A

Anti-Cholinergic (parasympathemimetic)

used in myasthenia gravis, symptomatic unstable sinus bradycardia, uveitis, anticholinesterase poisoninf and scorpion stings

disinhibits parasympathetics by blocking them and allowing sympathetic stimulation

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13
Q

Scopolamine

A

Anti-Cholinergic

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14
Q

Tropicamide

A

Anti-Cholinergic

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15
Q

Benztropine

A

Anti-Cholinergic used to decrease extrapyramidal symptoms and to decrease Parkinson effects

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16
Q

Biperiden

A

Anti-Cholinergic

17
Q

Trihexyphenidyl

A

Anti-Cholinergic

18
Q

Oxybutynin

A

Anti-Cholinergic

19
Q

Tolterodine

A

Anti-Cholinergic

20
Q

Solifenacin

A

Anti-Cholinergic

21
Q

Dicyclomine

A

Anti-Cholinergic

22
Q

Darifenacin

A

Anti-Cholinergic

23
Q

Ipratropium

A

Anti-Cholinergic used to induce bronchodilation

24
Q

Tiotropium

A

Anti-Cholinergic

25
Q

How is acetylcholine synthesized, excreted and Degraded

A
  1. acetyl CoA is added to choline by choline acetyltransferase
  2. excreted into synaptic cleft by vesicular exocytosis
  3. Acetylcholinesterase breaks down the ACh into acetyl coA and choline, which is recycles into the presynaptic neuron via choline/ Na trasporter
26
Q

how do organophosphates relate to cholinergics and what is the antidote

A

they cause excessive activation of muscarinic and nicotinic receptors

(all faucets turned on)

Give atropine to block excessive ACh

Give Pralidoxime to regenerate cholinesterase and decrease ACh levels in nicotinic receptor stimulation

27
Q

Describe anticholinergic syndrome

A

Dry mouth, warm, flushed skin, thirst, tachycardia, arrhythmias, mydriasis (dilated pupils), confusion, and agitation