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Pharm > AntiNeoplastic Drugs > Flashcards

AntiNeoplastic Drugs Flashcards

1
Q

Cyclophosphamide

  • MOA
  • Side Effects
A

MOA:

Nitrogen mustard prodrug, that forms covalent bonds with guanine, resulting in the crosslinking of DNA, preventing replication and transcription

Side Effects:

  • hemorrhagic cystitis
  • pulmonary fibrosis
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2
Q

DNA Alkylating Agents

MOA

Common Side Effects

A

MOA

results in cross-linking of DNA to prevent DNA replication and transcription

Ex: Nitrogen mustards, Inorganic platinum derivatives, Nitrosureas

Side Effects

Myelosuppression

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3
Q

Which group of DNA Alkylating agents NOT cause alopecia?

A

Nitrosureas

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4
Q

Inorganic Platinum Derivatives

MOA

Side Effects

A

MOA

reacts with water to form cytotoxic intermediates that react with guanine to cause interstrand cross linking between neighboring guanine residues

Myelosuppression

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5
Q

Cistplatin side effects

A

Nephrotoxicity

Ototoxicity

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6
Q

Oxaliplatin Side Effects

A

peripheral neuropathy

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7
Q

Busulfan

MOA

Side Effects

A

MOA

similar to cyclophosphamide, but prevents replication and transcription of myeloid cells

Side Effects: Pulmonary Fibrosis

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8
Q

Temozolomide

MOA

A

MOA:

causes DNA methylation of guanine residues, but does not cause crosslinking

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9
Q

Nitrosureas

MOA

A

MOA: form active intermediated that cross link DNA

Ex: Carmustine, Lomustine, Semustine

Side Effects: Pulmonary Toxicity

CNS Penetration

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10
Q

Additional Carmustine side effects

A

renal toxicity

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11
Q

DNA Intercalating Agents

MOA

Common Side Effects

A

MOA:

insert themselves into paired DNA bases, causing uncoiling and interfering with topoisomerase 2, causing free radicals

Ex: Doxorubicin/ Adriamycin, Daunorubicin, Dactinomycin, Epirubicin

Side Effects:

Mucosal ulcers

All cause alopecia except Daunorubicin

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12
Q

Doxorubicin/ Adriamycin Side Effects

A

Cardiotoxicity

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13
Q

Daunorubicin Side Effects

A

cardiotoxicity

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14
Q

Bleomycin

MOA

Side Effects

A

MOA:

intercalates DNA during G2 phase, causing catalyzed free radical formation and DNA strand breakage

Side Effects:

Pulmonary fibrosis, pneumonitis

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15
Q

Vinca Alkyloids

MOA

Side Effects

A

MOA:

bind to tubulin to prevent polymerization, stopping microtubule formation and inhibiting mitosis

Ex: vincristine, vinblastine, vinorelbine

Side Effects: Myelosuppression

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16
Q

Vincristine Side Effects

A

peripheral neuropathy

neurotoxicity

hoarseness

facial palsy

alopecia

abd pain

constipation

oral ulcers

17
Q

Taxanes

MOA

Side Effects

A

MOA:

binds to tubulin to prevent depolymerization, which promotes formation of stable but nonfunctional microtubules during mitosis

Ex: Paclitaxel, Docetaxel

Side Effects: Alopecia and neurotoxicity

18
Q

Topoisomerase 2 inhibitors:

MOA

Side Effects

A

MOA:

cause permanent strand breaks in DNA by preventing resealing of nicked strands

Ex: Etoposide, Teniposide, Irinotecan, Topotecan

Side Effects:

alopecia, secondary nonlymphocytic leukemias

19
Q

Imatinib

MOA

Side Effects

A

MOA: tyrosine kinase inhibitor that inhibits BCR-aBL and c-kit

Side effects: rash, edema, and pain

20
Q

Geftinib

MOA

A

MOA:

targets epidermal growth factor receptors and inhibits tyrosine kinase

21
Q

Erlotinib

MOA

Side Effects

A

MOA: inhibits tyrosine kinase associated with epidermal growth factor receptor

Side Effects:

rash, diarrhea, fatigue, dyspnea

Pharm (10 decks)

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