Gout Drugs

Question 1

MOA of Indomethacin

Answer 1

inhibits COX, thus inhibiting prostaglandin synthesis and urate crystal phagocytosis

Question 2

Side Effects of Indomethacin

Answer 2

GI ulceration

bleeding

HA

tinnitus

dizziness

confusion

Question 3

MOA of Colchicine

Answer 3

Binds to intracellular tubulin, preventing its polymerization into microtubules

• Leukocytes won’t be able to migrate or phagocytize

Question 4

MOA of Probenecid and Sulfinpyrazone

Answer 4

• completely inhibits the reabsorption of uric acid by renal tubules
• increases the excretion of uric acid Inhibits prostaglandin synthesis

Question 5

Side effects of Probenecid

Answer 5

Inhibits excretion of other drugs urolithiasis

GI disturbance

Dermatitis

Blood dyscrasias

Question 6

Side effects of Sulfinpyrazone

Answer 6

sulfa allergy

Question 7

MOA of Allopurinol and Febuxostat

Answer 7

inhibits xanthine oxidase to decrease plasma urate levels

Question 8

Side Effects of Allopurinol

Answer 8

Peripheral neuritis

Necrotizing vasculitis

aplastic anemia

bone marrow suppression

hypersensitivity

hepatitis

Reduce Azathioprine and 6MP

Question 9

Side Effects of Febuxostat

Answer 9

Increased LFTs

Nausea

Arthralgias

Rash

Question 10

MOA of Pegloticase

Answer 10

recombinant uricase that attaches to methoxy polyethylene glycol