Bone Disorder Drugs

Question 1

MOA of Bisphosphonates

Answer 1

prevents bone resorption by inhibiting osteoclast activity

Question 2

Side Effects of Bisphosphonates

Answer 2

jaw necrosis
atypical femur fracture
esophageal erosion

Question 3

MOA of Teripeptide

Answer 3

recombinant PTH analog that decreases osteoblast activation

Question 4

Side Effects of Teripeptide

Answer 4

Osteosarcoma

Question 5

MOA of Denosumab

Answer 5

Anti-RANKL monoclonal antibody that inhibits osteoclast maturation by mimicking OPG

Question 6

Side Effects of Denosumab

Answer 6

hypercholesterolemia
cystitis 
rash
eczema
dermatitis
MSK pain
hypocalcemia

Question 7

MOA of Raloxifene

Answer 7

selective estrogen receptor modulator that reduces bone resorption and increases bone density
-also lowers cholesterol and LDL

Question 8

Side effects of Raloxifene

Answer 8

hot flashes

thrombosis

Question 9

MOA of Tamoxifen

Answer 9

Selective estrogen receptor modulator that agonizes estrogen receptors in the bone and uterus
-antagonizes receptors in breast

Question 10

Tamoxifen side effects

Answer 10

hot flashes
hypercalcemia
endometrial cancer
thrombosis

Question 11

MOA of Calcitonin

Answer 11

directly binds to osteoclast receptors to inhibit activity and lower serum calcium