Cholinergic Receptors Flashcards
Where are M1 receptors located?
CNS and ganglia
Which M receptors are GPCR with Gq/11?
M1, M3 and M5
Which M receptors are GPCRs with Gi/o?
M2 and M4
What is the mechanism for M1, M3 and M5 receptors?
Activation of phospholipase C (PLC)
IP3 and DAG cascade
Where are M2 receptors found?
Heart, nerves, smooth muscle
What is the mechanism for M2 and M4 receptors?
Inhibition of adenylyl cyclase
Decreased cAMP production
Activation of K channels
Where are M3 receptors found?
Glands, SM and endothelium
Where are M4 receptors found?
CNS
Where are M5 receptors found?
CNS
Where are Nm receptors found?
Skeletal muscle neuromuscular junction
Where are Nn receptors found?
Post ganglionic cell body, dendrites, CNS
What are the structural features for Nn and Nm receptors?
Ligand gated ion channel
What is the mechanism of action for Nn and Nm receptors?
Na+, K+ depolarizing ion channel
