Cholinergic Neurotransmission Flashcards
1
Q
Substrates for ACh
A
Choline + Acetyl-CoA
2
Q
How is Choline driven into receptors?
A
Choline & Na+ cotransport
3
Q
Enzyme that binds Choline and acetyl-CoA
A
Choline acetyltransferase
4
Q
How is ACh released from synpatic cleft?
A
Ca++
5
Q
What toxin facilitates ACh release?
A
Black Widow spider toxin
Latrotoxin
Spastic paralysis
6
Q
What toxin blocks ACh release?
A
Botulinum toxin
Flaccid paralysis
7
Q
What drug inhibits uptake of choline and Na+?
A
Hemicholinium
8
Q
What drug prevents ACh from being packaged into vesicles?
A
Vesamicol
