Atherosclerosis Flashcards
1
Q
Risk factors
A
HTN
HLP
DM
Smoking
2
Q
Pathology of atherosclerosis
A
- Endothelial dysfunction
- Accumulation of lipoproteins
- Monocyte adhesion to endothelium
- Factor release
- Smooth muscle cell proliferation
- Lipid accumulation
3
Q
Endothelial dysfunction
A
Some level of loss or damage to the endothelium of the arteries
4
Q
Accumulation of lipoproteins
A
Lipoproteins accumulate –> LDL gets oxidized
5
Q
Monocyte adhesions
A
Monocytes move into the intima –> transforms into Macrophages –> Foam Cells
6
Q
Foam Cells
A
Macrophages full of lipids
7
Q
Factor release
A
Activated platelets
Macrophages
Inflammatory mediators
Cytokines
8
Q
Smooth muscle proliferation
A
smooth muscle cells migration/proliferation into the intima (normally in media)
Deposition of extracellular matrix: elastin & collagen
9
Q
Lipid accumulation
A
continued accumulation of lipids both extracellularly and within macrophages and smooth muscle cells
