Cholinergic Agonists Flashcards
Location of Acetylcholine
Pre & Post-ganglionic neuron
Somatic nerves
CNS
Muscarinic 1 Gq linked receptor in the CNS will result in
modulation of neurotransmission
Muscarinic 2 Gi linked receptor in the heart will result in
Bradycardia
Muscarinic 1 Gq linked receptor in the Gastric glands will result in
Histamine release and secretion
Muscarinic 3 Gq linked will result in
Vasodilation, Miosis, Bronchoconstriction
Peristalsis
Urination
Nicotinic Receptor in the Ganglia results in
Excitation of post-synaptic neuron
Nicotinic receptor in the skeletal muscle results in
Skeletal muscle contraction
Indication of a non-selective cholinergic agonist Carbachol
Miotic agent during ophthalmic surgery
Indication of a muscarinic receptor agonist Bethanechol
Management of urinary retention in patients with BPH
Indication for nicotine
Smoking cessationIn
Indications of Pilocarpine
Chronic open-angle glaucoma
What is cevimeline (muscarinic receptor agonist) used for?
Used for Sjorgen syndrome and dry mouth in patients who have had radiation of the head & neck
Indication of Varenicline (partial nicotinic agonist)
Aid in smoking cessation
An autoimmune disease where antibodies are directed against nicotinic receptors in skeletal muscle
Myasthenia Gravis
Edrophonium
used in the diagnosis of Myasthenia gravis because upon administration, it rapidly increases Acetylcholine concentration at cholinergic synapse
