Andrenoreceptor Agonists until Selective B-1

Question 1

Location of Catecholamines

Answer 1

Sympathetic post-ganglionic neuron
Adrenal Medulla (Chromaffin Cells)
Central Nervous System

Question 2

Gs has a stimulatory effect on Adenylyl Cyclase as a result,

Answer 2

it increases cAMP

Question 3

Gi has inhibitory effect on Adenylyl Cyclase as a result,

Answer 3

it decreases cAmp

Question 4

Gq activation will release Phospholipase C which will synthesize DAG and IP3 as a result,

Answer 4

it will facilitate the release of calcium from the Sarcoplasmic Reticulum

Question 5

SR, CM, and Ca++ - CM means

Answer 5

Sarcoplasmic Reticulum, Calmodulin, Calcium-Calmodulin Complex

Question 6

MLC, MLCK, MLCP means

Answer 6

Myosin Light Chain, Myosin Light Chain Kinase, Myosin Light Chain Phosphatase

Question 7

cAMP and cGMP means

Answer 7

Cyclic Adenosine Monophosphate, Cyclic Guanosine Monophosphate

Question 8

IP3, DAG, and NO means

Answer 8

Inositol Triphosphate, Diacylglycerol, Nitric Oxide

Question 9

The Alpha 1 Gq-linked receptor in the Vascular smooth muscle will result in

Answer 9

Vasoconstriction

Question 10

The Alpha 1 Gq-linked receptor in the Urinary bladder will result in

Answer 10

Urinary Retention

Question 11

The Alpha 1 Gq-linked receptor in the Radial of the Iris will result in

Answer 11

Mydriasis

Question 12

The Alpha 1 Gq-linked receptor in the Pilomotor smooth muscles will result in

Answer 12

Contraction

Question 13

The Alpha 2 Gi-linked receptor in the CNS will result in

Answer 13

Inhibition of further release of Catecholamines

Question 14

The Alpha 2 Gq-linked receptor in the Peripheral blood vessels will result in

Answer 14

Vasoconstriction

Question 15

The Beta 1 Gs-linked receptor in the Heart will result in

Answer 15

Inotropy, Chronotropy, Dromotropy (basically, heartbeat and BP will increase)

Question 16

The Beta 2 Gs-linked receptor in the Bronchioles will result in

Answer 16

Bronchodilation

Question 17

The Beta 2 Gs-linked receptor in the Uterine muscles will result in

Answer 17

Uterine Relaxation

Question 18

The Beta 2 Gs-linked receptor in the Blood vessels will result in

Answer 18

Vasodilation

Question 19

The Beta 2 Gs-linked receptor in the Neuromuscular endplates will result in

Answer 19

Hypokalemia (lower K levels in the bloodstream)

Question 20

The Beta 2 Gs-linked receptor in the Liver will result in

Answer 20

Glycogenolysis (breakdown of glycogen to glucose-1-phosphate and glycogen)

Question 21

The Beta 3 Gs-linked receptor in the Adipose tissues will result in

Answer 21

Lipolysis

Question 22

The Dopamine 1 Gs-linked receptor in the Renal Blood Vessels will result in

Answer 22

Renal Vasodilation

Question 23

The Dopamine 2 Gi-linked receptor in the GIT will result in

Answer 23

Loss of peristalsis

Question 24

The Dopamine 2 Gi-linked receptor in the CNS will result in

Answer 24

Modulation of motor activity, perception, and behavior

Question 25

The Beta 1 Gs-linked receptor in the juxtaglomelular apparatus will result in

Answer 25

Release of renin

Question 26

Gq will activate the release of

Answer 26

Phospholipase C

Question 27

Phospholipase 3 will synthesize

Answer 27

IP3 (Inositol Triphosphate) and DAG (Diacylglycerol)

Question 28

Synthesis of DAG (Diacylglycerol) & IP3 (Inositol Triphosphate) will

Answer 28

Release of calcium from the Sarcoplasmic Reticulum

Question 29

Stimulates more than one general type of adrenergic receptor

Answer 29

Non-Selective Adrenoreceptor Agonist

Question 30

Properties of Endogenous catecholamines

Answer 30

Not Orally administered Acid Labile Metabolized by MAO and COMT

Question 31

Indications of Epinephrine

Answer 31

Counteracts the effects of histamine as a physiological antagonist Used for anaphylactic shock

Question 32

Indications of Norepinephrine "Levarterenol"

Answer 32

First line in the management of septic shock

Question 33

Indications of Dopamine

Answer 33

Can be used in the management of Cardiogenic shock and Septic shock

Question 34

Characteristics of Non-Catecholamines

Answer 34

Not substrates of COMT and MAO Effective after oral administration Relatively longer duration of action compared to Catecholamines

Question 35

Indications of Selective Alpha-1 Agonists

Answer 35

Nasal Congestion Reducing regional blood flow to achieve hemostasis during surgery Reducing diffusion in local anesthetics

Question 36

Adverse effects of Selective Alpha 1-Agonists

Answer 36

Rhinitis medicamentosa (rebound congestion) Urinary Retention Exacerbation of hypertension (elevation of blood pressure)

Question 37

Indications Selective Alpha-2 Agonists (CNS)

Answer 37

Clinically used to normalize blood pressure in patients w/ hypertension Acts by reducing sympathetic tone in the CNS

Question 38

Most common side/adverse effect of Selective Alpha-2 Agonist

Answer 38

Sedation

Question 39

Clonidine indications include

Answer 39

Hypertensive Urgency Management of ADHD Facilitate abstinence from opioid dependence

Question 40

Methyldopa FDA approved indication

Answer 40

Management of hypertension in pregnant women

Question 41

Non-Selective Beta Agonist

Answer 41

Isoproterenol "Isoprenaline"

Question 42

Indications for Isoproterenol

Answer 42

Alternative drug used for shock states and acute heart failure Previously used to treat bronchial Asthma

Question 43

Indications of Dobutamine

Answer 43

First line agent in the management of cardiogenic shock (increases cardiac output and stroke volume) Management of acute heart failure (as an inotropic agent)