Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PCOL 1 > Andrenoreceptor Agonists until Selective B-1 > Flashcards

Andrenoreceptor Agonists until Selective B-1 Flashcards

1
Q

Location of Catecholamines

A

Sympathetic post-ganglionic neuron
Adrenal Medulla (Chromaffin Cells)
Central Nervous System

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Gs has a stimulatory effect on Adenylyl Cyclase as a result,

A

it increases cAMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Gi has inhibitory effect on Adenylyl Cyclase as a result,

A

it decreases cAmp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Gq activation will release Phospholipase C which will synthesize DAG and IP3 as a result,

A

it will facilitate the release of calcium from the Sarcoplasmic Reticulum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

SR, CM, and Ca++ - CM means

A

Sarcoplasmic Reticulum, Calmodulin, Calcium-Calmodulin Complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MLC, MLCK, MLCP means

A

Myosin Light Chain, Myosin Light Chain Kinase, Myosin Light Chain Phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

cAMP and cGMP means

A

Cyclic Adenosine Monophosphate, Cyclic Guanosine Monophosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

IP3, DAG, and NO means

A

Inositol Triphosphate, Diacylglycerol, Nitric Oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The Alpha 1 Gq-linked receptor in the Vascular smooth muscle will result in

A

Vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The Alpha 1 Gq-linked receptor in the Urinary bladder will result in

A

Urinary Retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The Alpha 1 Gq-linked receptor in the Radial of the Iris will result in

A

Mydriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The Alpha 1 Gq-linked receptor in the Pilomotor smooth muscles will result in

A

Contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The Alpha 2 Gi-linked receptor in the CNS will result in

A

Inhibition of further release of Catecholamines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The Alpha 2 Gq-linked receptor in the Peripheral blood vessels will result in

A

Vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The Beta 1 Gs-linked receptor in the Heart will result in

A

Inotropy, Chronotropy, Dromotropy (basically, heartbeat and BP will increase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The Beta 2 Gs-linked receptor in the Bronchioles will result in

A

Bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

The Beta 2 Gs-linked receptor in the Uterine muscles will result in

A

Uterine Relaxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The Beta 2 Gs-linked receptor in the Blood vessels will result in

A

Vasodilation

19
Q

The Beta 2 Gs-linked receptor in the Neuromuscular endplates will result in

A

Hypokalemia (lower K levels in the bloodstream)

20
Q

The Beta 2 Gs-linked receptor in the Liver will result in

A

Glycogenolysis (breakdown of glycogen to glucose-1-phosphate and glycogen)

21
Q

The Beta 3 Gs-linked receptor in the Adipose tissues will result in

A

Lipolysis

22
Q

The Dopamine 1 Gs-linked receptor in the Renal Blood Vessels will result in

A

Renal Vasodilation

23
Q

The Dopamine 2 Gi-linked receptor in the GIT will result in

A

Loss of peristalsis

24
Q

The Dopamine 2 Gi-linked receptor in the CNS will result in

A

Modulation of motor activity, perception, and behavior

25
Q

The Beta 1 Gs-linked receptor in the juxtaglomelular apparatus will result in

A

Release of renin

26
Q

Gq will activate the release of

A

Phospholipase C

27
Q

Phospholipase 3 will synthesize

A

IP3 (Inositol Triphosphate) and DAG (Diacylglycerol)

28
Q

Synthesis of DAG (Diacylglycerol) & IP3 (Inositol Triphosphate) will

A

Release of calcium from the Sarcoplasmic Reticulum

29
Q

Stimulates more than one general type of adrenergic receptor

A

Non-Selective Adrenoreceptor Agonist

30
Q

Properties of Endogenous catecholamines

A

Not Orally administered

Acid Labile

Metabolized by MAO and COMT

31
Q

Indications of Epinephrine

A

Counteracts the effects of histamine as a physiological antagonist

Used for anaphylactic shock

32
Q

Indications of Norepinephrine
“Levarterenol”

A

First line in the management of septic shock

33
Q

Indications of Dopamine

A

Can be used in the management of Cardiogenic shock and Septic shock

34
Q

Characteristics of Non-Catecholamines

A

Not substrates of COMT and MAO

Effective after oral administration

Relatively longer duration of action compared to Catecholamines

35
Q

Indications of Selective Alpha-1 Agonists

A

Nasal Congestion

Reducing regional blood flow to achieve hemostasis during surgery

Reducing diffusion in local anesthetics

36
Q

Adverse effects of Selective Alpha 1-Agonists

A

Rhinitis medicamentosa (rebound congestion)

Urinary Retention

Exacerbation of hypertension (elevation of blood pressure)

37
Q

Indications Selective Alpha-2 Agonists (CNS)

A

Clinically used to normalize blood pressure in patients w/ hypertension

Acts by reducing sympathetic tone in the CNS

38
Q

Most common side/adverse effect of Selective Alpha-2 Agonist

A

Sedation

39
Q

Clonidine indications include

A

Hypertensive Urgency

Management of ADHD

Facilitate abstinence from opioid dependence

40
Q

Methyldopa FDA approved indication

A

Management of hypertension in pregnant women

41
Q

Non-Selective Beta Agonist

A

Isoproterenol
“Isoprenaline”

42
Q

Indications for Isoproterenol

A

Alternative drug used for shock states and acute heart failure

Previously used to treat bronchial Asthma

43
Q

Indications of Dobutamine

A

First line agent in the management of cardiogenic shock (increases cardiac output and stroke volume)

Management of acute heart failure (as an inotropic agent)

PCOL 1 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions