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Drugs > Cholesterol meds > Flashcards

Cholesterol meds Flashcards

1
Q

What drug inhibits HMG-CoA?

A

Statins

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2
Q

What is the primary therapeutic effect of statins?

A

Reduce synthesis of endogenous cholesterol by inhibiting the rate limiting step

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3
Q

What is the secondary positive therapeutic effect of statins?

A

Decreased LDL synthesis –> increased LDL receptor synthesis –> increased LDL catabolism

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4
Q

What is ezetimibe?

A

Cholesterol absorption inhibitor

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5
Q

How do bile acid resins decrease LDL?

A

Exogenously (increased fecal loss of bile salt-bound LDL)

Endogenously (liver uses more cholesterol to make more bile salt)

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6
Q

What are examples of bile acid resins?

A

Cholestyramine
Colestipol
Colesevelam

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7
Q

Which type of cholesterol drugs have the highest increase in HDL?

A

Niacin (B3)

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8
Q

What are gemfibrozil, clofibrate, bezafibrate, fenofibrate?

A

Fibrates

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9
Q

What is the effect of fibrates?

A

Up-regulates LPL –> increased TG clearance –> small decrease in LDL and small increase in HDL

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Drugs (6 decks)

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