Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Drugs > Antiarrhythmatics rhythm > Flashcards

Antiarrhythmatics rhythm Flashcards

1
Q

Disopyramide, Quinidine, and Procainamide belong to which class of antiarrhythmatics?

A

Class 1A

Double Quarter Pounder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the Class 1B drugs?

A

Lidocaine and Mexilitine

Lettuce and Mayo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Flecainide and Propafenone belong to which class of antiarrhythmatics?

A

Class 1C

Fries Please

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the direct effect of Class 1A drugs?

A

Delay opening of the fast sodium gates

Slow both the rate of activation and reactivation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the direct effect of Lidocaine and Mexilitine?

A 
Delay opening of the fast sodium gates
Enhance reactivation (dissociate quickly)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the direct effect of Class 1C drugs?

A

Delay opening of the fast sodium gates

Slow the rate of activation of the sodium gates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the indirect effects of Quinidine?

A

Strongly vagolytic
Moderate α-adrenergic block
(Reflex β1 stimulation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the indirect effect of Procainemide and Disopyramide?

A

Weakly vagolytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the overall effect of Quinidine?

A

Variable effects on sinus rate and PR interval
Widen QRS complex
Prolong QT interval

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What causes the variable effects of Quinidine?

A

The vagolytic activity…can increase HR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the overall effect of Procainemide and Disopyramide?

A

Consistent slight slowing of pacemaker and slight prolonging PR interval
Widen QRS complex
Prolong QT interval

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why are Procainemide and Disopyramide more consistent?

A

Less vagolytic activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which Class 1A antiarrhythmatic is eliminated primarily by the liver?

A

Quinidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which Class 1A drug should not be given to patients with renal failure?

A

Procainemide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where is Disopyramide eliminated?

A

Liver and kidney (50/50)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What arrhythmias can Quinidine and Procainemide be used to treat?

A

Atrial flutter and A fib
PVCs
Sustained VT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What Class 1A drug can be used to treat ONLY sustained VT?

A

Disopyramide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which Class 1A drug is most likely to cause severe diarrhea?

A

Quinidine…“the quinidine shits”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which Class 1A drug is most likely to cause SLE-like symptoms?

A

Procainemide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What does Disopyramide adversely effect? How?

A

CNS

Anti-ACh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What effect do Class 1B drugs have on ECGs?

A

Slight shortening of the QT interval

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Which Class 1B drug has a higher oral bioavailability?

A

Mexilitine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Where are Lidocaine and Mexilitine eliminated?

A

Liver

24
Q

What are the adverse effects of Lidocaine?

A

CNS-confusion

Disorientation

25
Q

What are the adverse effects of Mexilitine?

A

Neurological

26
Q

What are the effects of Class 1C drugs on ECGs?

A

Slightly prolong PR interval

Widen QRS complex

27
Q

What did CAST studies of Class 1C drugs determine?

A

Higher mortality rate

28
Q

What are Flecainide and Propafenone used for?

A

Long-term management of recurrent VT that is unresponsive to other drug therapies

29
Q

Which Class 1C drug has a higher oral bioavailability?

A

Flecainide

30
Q

Which Class 1C drug should not be given to hepatitis patients?

A

Propafenone

31
Q

Which drug may cause sinus slowing and/or an AV block?

A

Flecainide

32
Q

What are the adverse side effects of Propafenone?

A

VT
Heart failure
AV block

33
Q

What do beta-blockers end in?

A

-alol

34
Q

What are the significant effects of beta-blockers?

A

Slow sinus rate

Prolong PR interval

35
Q

What arrhythmias are beta-blockers used for?

A

Supraventricular tachyarrhythmias

Exercise-induced ventricular tachyarrhythmias

36
Q

Where are beta-blockers eliminated?

A

Liver

37
Q

What are the adverse effects of beta-blockers?

A

Sinus bradycardia
AV conduction block
Contractile failure

38
Q

What are Class 3 anti-arrhythmatics?

A

Inhibit closing (phase 4) and re-opening (phase 3) of potassium channels

39
Q

What are the effects of the potassium blockers?

A

Slow the sinus rate
Prolong the PR interval
Widen the QRS
Prolong the QT interval

40
Q

What are the Class 3 anti-arrhythmatics?

A

Amiodarone
Ibutilide
Dofetilide

41
Q

Which Class 3 drug is used for life-threatening VT and for supraventricular arrhythmias?

A

Amiodarone

42
Q

What are ibutilide and dofetilide used for?

A

Atrial flutter

A fib

43
Q

What is the most worried about adverse effect of Class 3 anti-arrhythmatics?

A

Torsades de Pointes

44
Q

Nodes?

A

Calcium blockers!!

45
Q

What are the calcium channel blockers?

A

Verapamil

Dilitazem

46
Q

What is verapamil used for?

A

Supraventricular arrhythmias

47
Q

Where are calcium blockers eliminated?

A

Liver

48
Q

What are the adverse effects of calcium blockers?

A

Hypotension
Sinus bradycardia
AV conduction block
Ventricular failure

49
Q

What does adenosine do?

A

2 mechanisms. Inhibits cAMP-induced calcium influx and increases potassium permeability to hyperpolarize cells.

50
Q

What is adenosine used for?

A

Converts life-threatening PSVT to normal sinus rhythm

51
Q

What does digitalis do?

A

Supraventricular tachyarrhythmias

Converts PSVT to normal sinus rhythm

52
Q

What are the risks of digitalis?

A 
AV block
Sinus bradycardia (give atropine to block ACh receptors)
Can increase PVC's...raise RMP closer to threshold
53
Q

How should Atrial Flutter be treated?

A

Class III antiarrhythmia

Ibutelide, Dofetilide

54
Q

How should A Fib be treated? With heart disease?

A

Beta blocker + Calcium blocker (Diltiazem, Verapamil)

Amiodarione

55
Q

How should Multifocal Atrial Tachycardia be treated?

A

Verapamil + beta blocker (metoprolol)

56
Q

How should Supraventricular Tachycardia be treated?

A

Joules/Adenosine

Verapamil

Drugs (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions