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Drugs > Adrenergics > Flashcards

Adrenergics Flashcards

1
Q

What is the preferential binding to beta-1?

A

Isoproterenol > epinephrine = norepinephrine

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2
Q

What is the preferential binding to alpha-1?

A

Epinephrine >/= norepinephrine&raquo_space; isoproterenol

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3
Q

What is the preferential binding to beta-2?

A

Isoproterenol > epinephrine&raquo_space; norepinephrine

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4
Q

What is the preferential binding to alpha-2?

A

Epinephrine >/= norepinephrine&raquo_space; isoproterenol

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5
Q

What is the effect of beta-1 activity on blood pressure?

A

Beta-1 increases HR and SV

BP=(HR)(SV)(TPR)

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6
Q

What are the effect of alphas-1&2 activity on blood pressure?

A

Alpha-1 increases TPR
Alpha-2 decreases TPR

BP=(HR)(SV)(TPR)

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7
Q

What is the effect of beta-2 activity on blood pressure?

A

Beta-2 decreases TPR

BP=(HR)(SV)(TPR)

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8
Q

Besides the alphas and betas, what other receptor activity can effect BP?

A

Muscarinic receptors

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9
Q

What transmitter binds to muscarinic receptors?

A

Acetylcholine

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10
Q

What is the effect of muscarinic activity on blood pressure?

A

Decreases HR and TPR

BP=(HR)(SV)(TPR)

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11
Q

What is the transmitter from the pre-ganglionic fibers? What kind of receptor is used in the sympathetic pathway?

A

ACh

Nicotinic receptor

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12
Q

What is a fancy ganglion?

A

Adrenal Medulla

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13
Q

What receptor(s) are activated by dopamine?

A

Beta-1 and alpha-1

Dope is #1! So Beta1 and alpha1

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14
Q

Because dopamine activates beta-1 and alpha-1 receptors, what is its effect on BP?

A

Dopamine will increase BP

Beta-1 increases HR and SV
Alpha-1 increases TPR

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15
Q

What would be necessary to inhibit dopamine activity?

A

Alpha-1 blocker (Terazosin)
Beta-1 blockers (MAA)

Non-selectives
Alpha (Trazadone)
Beta (non-MAA -alol’s)

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16
Q

What is Dobutamine?

A

Dobutamine is a beta-1 agonist. butamIne is beta1. Buta, beta, its close. i is like 1. so Beta 1. “Will be on the test”

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17
Q

What is the effect of Dobutamine on BP?

A

Dobutamine increases BP

Beta-1 increases HR and SV

18
Q

Is Dobutamine permanent?

A

No…Dobutamine reversibly binds to beta-1 receptors

19
Q

What would be needed to block Dobutamines effects?

A

Beta-1 blockers (MAA)

Non-specific beta-blockers

20
Q

What is an alpha-1 agonist?

A

Phenylephrine
(ends in ephrine, so it acts like epi and targets alpha-1, thats how Jeff remembered it in simpler times.Still kinda works)

21
Q

What effect does Phenylephrine have on BP?

A

Phenylephrine increases BP

Alpha-1 increases TPR

22
Q

What would be needed to block Phenylephrines effects?

A

Alpha-1 blocker (terazosin)

Non-specific alpha-blocker (trazadone)

23
Q

What are some examples of beta-2 agonists?

A 
Metaproterenol
Terbutaline
Albuterol
Ritodrine (delays labor)
Salmeterol

Mnemonic alert: Beta 2 increases blood flow. What needs more blood flow? Erections.

Men Think About Raunchy Sex

24
Q

What effect do beta-2 agonists have on BP?

A

Beta-2 agonists decrease BP

Beta-2 decreases TPR

25
Q

What would inhibit the effects of beta-2 agonists?

A

Non MAA beta-blockers

26
Q

What effect do Clonidine, alpha-Methyldopa, and Guanabenz have on BP?

A

They decrease BP

27
Q

What causes Clonidine, alpah-Methyldopa and Guanabenz to DEcrease BP?

A

They are alpha-2 agonists… suppress sympathetics through actions in medulla oblangata

28
Q

What drug would block the effects of the alpha-2 agonists?

A

Trazadone

29
Q

What is the effect of cocaine and imipramine?

A

Potentiate sympathetics…block reuptake by nerves

Increases blood pressure

30
Q

What is the effect of tyramine/amphetamine/ephedrine?

A

Release of norepinephrine by reversing axoplasmic uptake pump

Increases blood pressure

Remember how ephedrine was like amphetamine durin CPC last year?

Just freaking remember tyramine, its one drug, don’t worry about mnemonic.

31
Q

What is the effect of Reserpine?

A

Jeff edited this. Depletes norepinephrine…blocks vesicular uptake

Decreases blood pressure

His PowerPoint stated what I put on there. It did say vascular before, which his notes said. But that doesn’t make sense where power point explanation is more clear.

32
Q

What is the effect of Guanethidine/guanadrel?

A

Depletes norepinephrine..releases norepinephrine from vesicles

GUAN is GONE (in terms of norepinephrine is GONE)

Decreases blood pressure

33
Q

What drug can stop effect of Tyramine?

A

Cocaine. Blocks the axoplasmic pump that Tyramine, amphetamine and ephedrine would use.

34
Q

What can’t you eat if on pargyline?

A

Tyramine. It is an MOA inhibitor so you have moe catechu lameness. Remember that Tyramine acts like amphetamine and causes release into blood stream

35
Q

What is pargyline?

A

Irreversible MAO

36
Q

What is the beta 2 agonist that starts with M?

A

Metaproterenol (Men)

37
Q

What is the beta 2 agonist that starts with T?

A

Terbutaline (Think)

38
Q

What is the beta 2 agonist that starts with A?

A

Albuterol (About)

39
Q

What is the beta 2 agonist that starts with R?

A

Ritodrine (used to delay labor) [Raunchy]

40
Q

What is the beta 2 agonist that starts with S?

A

Salmetrol (Sex)

Drugs (6 decks)

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