Cholesterol and Lipid Metabolism Drugs Flashcards
1
Q
Give examples of statins
A
Simvastatin
Atorvastatin
2
Q
How do statins inhibit cholesterol synthesis?
A
Act as competitive inhibitors of HMG-CoA reductase
3
Q
Give examples of fibrates
A
Bezafibrate
Gemfibrozil
4
Q
How do fibrates work?
A
Act as agonists of the PPARalpha receptor
5
Q
Give an example of a bile acid binding resin
A
Cholesevelam
6
Q
How do bile acid binding resins reduce cholesterol?
A
Cause excretion of bile salts causing more cholesterol to be converted to bile salts
7
Q
How does ezetimbe reduce absorption of cholesterol?
A
Inhibits the NPC1L1 transport protein preventing cholesterol from crossing the membrane
