Anti-Arrhythmic Drugs

Question 1

What channels do class I agents block?

Answer 1

Sodium channels

Question 2

In what state do class I agents bind and dissociate from sodium channels?

Answer 2

Bind in open state

Dissociate in resting state

Question 3

Give examples of class I agents

Answer 3

Lignocaine

Flecainide

Question 4

Class I agents are rate control drugs. True/false?

Answer 4

False

Rhythm control drugs

Question 5

In what arrhythmia is lignocaine used?

Answer 5

Ventricular arrhythmias

Question 6

Flecainide is used in atrial fibrillation. True/false?

Answer 6

True

Question 7

What receptors do class II agents block?

Answer 7

Beta receptors

Question 8

Class II agents increase rate of depolarisation in SA and AV nodes. True/false?

Answer 8

False

Decrease rate of depolarisation

Question 9

Are class II agents rate controllers or rhythm controllers?

Answer 9

Rate controllers

Question 10

Propranolol/atenolol can control what arrhythmia?

Answer 10

SVT

Question 11

What channels do class III block?

Answer 11

Potassium

Question 12

What effect do class III agents have on action potential?

Answer 12

Prolong it (thus increase refractory period

Question 13

Class III agents control rhythm/rate?

Answer 13

Rhythm

Question 14

Give examples of class III agents and when they are used

Answer 14

Amiodarone and sotalol

Used in SVT and VT

Question 15

What channels do class IV drugs block?

Answer 15

Calcium channels

Question 16

What effect do class IV agents have on conduction?

Answer 16

Slow conduction in SA and AV nodes to decrease force of contraction

Question 17

Class IV agents control rate. True/false?

Answer 17

True

Question 18

Give an example of a class IV agent?

Answer 18

Verapamil

Question 19

When are class IV agents used?

Answer 19

Supraventricular arrhythmias (atrial flutter/atrial fibrillation)