Cholesterol Flashcards
1
Q
Content of lipid rafts
A
Cholesterol + sphingolipids + GPI
2
Q
Cholesterol derivatives
A
Vitamin D
Bile salts
Steroid hormones
3
Q
3 steps of cholesterol synthesis
A
Synthesis of iso
Condensation of 6 x iso —> squalene
Cyclisation of squalene + 19 steps
4
Q
Heart disease cause and what is targeted
A
Blocked coronary artery
HMG-CoA reductase targeted by drugs such as lovastatin (comp.in.)
Bile acid binders inhibit intestinal reabsorption of bile salts.
5
Q
FH disease
A
No LDL receptor for cholesterol.
Homozygous die of heartd.
Heterozygotes have heartd. Later
