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Farmacologia > Chinoloni/fluorochinoloni > Flashcards

Chinoloni/fluorochinoloni Flashcards

1
Q

Chi

A

Acido nalidixico
Cinoxacina
Ciprofloxacina
Levoflixacina

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2
Q

Cosa fanno

A

Inibiscono topoisomerasi 4 (gram+) e DNA girasi (-)

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3
Q

Azione

A

Battericida

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4
Q

Resistenze

A

Mutazioni cromosomiche batteriche che provocano alterazione dell’entità bersaglio o una riduzione della permeabilità delle membrane batteriche

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5
Q

Spettro

A

Ampio
Gram-
Gram+

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6
Q

Via somm

A

Orale
Endovenosa in casi gravi (ciprofloxacina)
Intramuscolare, irritante e dolorosa

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7
Q

Usi

A

Infezioni vie aeree
Urinarie (buona distribuzione)
Più gravi dermatologiche
Intestinali
Mst
Chemioprofilassi
Emivita lunga, 12h, 2/3 volte al giorno

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8
Q

Meccanismo

A

Concentrazione dipendente l

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9
Q

Metabolismo

A

Escreto dal rene in forma inalterata o come metabolita attivo

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10
Q

Reazioni avverse

A

Gastrointestinali
No gravidanza, no bambini
Abbassamento soglia convulsioni
Astenia
Vertigini
Turbe sonno
Tendiniti

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Farmacologia (25 decks)

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