Chillout 2 Flashcards
Medussa head
locks of matted hair
Bacillus Anthracis
Pathogenic factors of anthrax
Lethal and Edema - kills
Protective antigen - mediates entry
What type of anthrax that kills?
Pulmonary anthrax
“woolsorter’s disease”
Hemorrhagic pneumonia..
death in 1 to 3 days.
Spore inhilation
Pulmonary anthrax
MC type of anthrax
Cutaneous(95%)
tx for anthrax
PEN G
erythromycin
vaccine
Malignant postule is aka
Black eschar
Two toxins of Bacillus cereus
Enetic - fried rice
Diarrheal - meat dishes and sauces
Bacillus anthracolis is made up of….
Poly D Glutamate
What is life-threatening pneumoniancharacterized by mediastinal hemorrage lymphadenitis?
Woolsorter’s disease or Pulmonary Anthrax
Warm food poisoning
B. cereus
Malignant pustules and CENTRAL necrosis or eschar formation with painful regional lymphadenopathy
Cutaneous anthrax
Slow growing obligate aorobe
Slipping and Snapping forms
(+) niacin
Catapase (-) @ 68 degress
MTB
Serpentine growth
MTB
What causes the serpentine growth in vitro?
also responsible for virulence
Cord Factor - Trehalose Dimycolate
how many weeks does MTB need to be positive for culture?
6 weels
responsible for caseous necrosis
phosphatides
Granuloma with typical Langhan’s giant cells, epithelioid cells and fibrosis
Classic tuhular lesion of MTB
Conditions with
apical infiltrates and perihilar cavitations
Wegener’s granulomatosis
Sarcoidosis
MTB
Provides a definitive dx for active TB
Direct sputum mocroscopy
Bone TB in children and in adult location
Upper thoracic: children
Lower thoracic/upper lumbar infiltrates: adults
Skip lesions and cobblestone appearance conditions
TB
Crohn’s
Difference in TB and Crohns
Granuloma in TB
Most common initial presentation of PTB
wt loss
most common extrapulmonary sitenof TB
LN
Best initial test for TB
CXR
Positive PPD is defined as
Induration equal or greater than 10mm after 4i8 to 72 hours after injection
Positive PPD test in HIV px
5mm
Natural Resistance Assoc Macrophage protein (NRAM) genetic protein
BEG gene
Mycobacrerium avium intracellulare
Anti TB drugs should have these 3 properties
bactericidal
sterilizing
ability to prevent resistance
First line TB drugs
Isoniazid Rifampin Ethambutol Pyrazinamide Streptomycun
Second line drugs for TB
Quonolones
Aminoglycosides
Hansens disease
Leprosy
Toxin of M. leprae
NONE
the only bacterium that invades peripheral nerves
M. leprae
M. leprae cell wall contains what?
phenolic glycolipid(PGL-1)
M.leprae like this types of temp and tissues
Cool skin and extremities
32C-34C
Packs of cigars in microscope
M. leprae