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Pharm > Chemotherapy I > Flashcards

Chemotherapy I Flashcards

1
Q

Skipper Hypothesis

A

The ability of chemotherapy to cure is inversely proportional to the tumor burden

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2
Q

Cytotoxicity

A

= efficacy of the drug (in killing cancer cells)

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3
Q

Toxicity

A

= side effects

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4
Q

Partial remission

A

> 50% reduction in tumor burden

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5
Q

Phase I clinical trials

A

determine dose and dose limiting toxicity

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6
Q

Phase II clinical trials

A

Determine Activity

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7
Q

Phase III clinical trials

A

Determine efficacy

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8
Q

Constitutional toxicities

A

Nausea, vomiting
Loss of appetitie
Fatigue

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9
Q

Toxicities due to effect on normal dividing cells

A 
Myelosuppression
Temporary hair loss
Mucositis, sore mouth
Diarrhea
Sterility
Menopause
Secondary neoplasms
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10
Q

Organ specific toxicity of anthracyclines (doxorubicin)

A

Cardiac toxic

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11
Q

Organ specific toxicity of Bleomycin

A

Pulmonary toxicity

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12
Q

Organ specific toxicity of cis-DDP (cisplatin)

A

Nephrotoxicity

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13
Q

Absolute neutrophil count

A

White blood cell count x (%neutrophils + % bands)

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14
Q

Nadir

A

Lowest neutrophil count

10-14 days after dose

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15
Q

What can you give to prevent neutropenia?

A

Colony stimulating factors
Filgrastim (G-CSF)
*DO NOT start after already neutropenic

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16
Q

Febrile neutropenia

A

ANC less than 500, fever greater than 100.5 F

give broad spec Antibiotics

17
Q

Thrombocytopenia

A

platelet transfusion if less than 10,000 or low platelet count at any levels and patient is bleeding

18
Q

Anemia

A

Blood transfusions

19
Q

Agents to give for nausea/vomiting

A 
*ONDANSETRON
prochlorperazine
Selective serotonin antagonists
Corticosteroids
Lorazepam (anticipatory)
Aprepitant
20
Q

Side effects of anti-emetics
Dexamethason:
Compazine:
Ondansetron:

A

Dexamethason: elevated sugars
Compazine: Extrapyramidal
Ondansetron: prolonged QT

21
Q

Stomatitis

A

Inflammation of mucus membranes of mouth
Give magic mouthwash
+/- nystatin for oral fungal infection
Self-limiting

22
Q

Vesicants

A

A substance that causes tissue blistering
Ex. viscristine, vinblastine, doxorubicin, daunorubicin
Portacath

Pharm (20 decks)

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