Chemotherapy Flashcards
How many cells must be in a tumour before it can be physically detected?
10^9
In what cases in curative chemotherapy used
Solid tumours
What is meant by each letter in the TMN score
T= tumour- local mass and extension N= nodes- has it reached nodes M= metastasis- has it spread systemically
What is the purpose of adjuvant chemotherapy
To eridicate or control micro-metastasis
What are the 3 functions of neo-adjuvant chemotherapy
To make surgery or RT possible
To alleviate surgical damage
To eradicate micro-metastasis
In what malignancies is chemotherapy the primary treatment
Haematological malignancies
Define ‘specific cell cycle phase drug’
What does its action depend upon?
Agents with major activity in particular phase of cycle
Schedule dependent
Define ‘non specific cell cycle phase drug’
What does its action depend upon?
Agents with significant activity in multiple phases
Dose dependent
Name 5 non phase specific drugs
- Cyclophosphamide
- Chlorambucil
- Cisplatin
- Actinomycin- D
- L- asparaginase
Name a drug that acts in the G1 phase
Vinblastine
Name a drug that acts in the S phase (3)
Methotrexate
6-Mercaptopurine
5-Fluorouracil
Name the drugs that act in G2 phase v(4)
Bleomycin
Etoposide
Topotecan
Daunorubicin
Name the drugs that act in the M phase (4)
Vincristine
Vinblastine
Paclitaxel
Docetaxel
Where do antimetabolites act?
At DNA synthesis
Where do alkylating agents act
Directly upon the DNA
