Chemotherapy

Question 1

alkylating agents

Answer 1

cyclophosphamide (nitrogen mustard)

cisplatin (platinum compounds)

Question 2

Mitotic inhibitors

Answer 2

vincristine

paclitaxel

Question 3

anti-tumor antibiotic

Answer 3

doxorubicin

Question 4

antimetabolites

Answer 4

methotrexate

Question 5

topoisomerase inhibitor

Answer 5

irinotecan

Question 6

selective toxicity

Answer 6

kill rapidly dividing cells while sparing slowly dividing normal cells

Question 7

MOA: alkylating agents

Answer 7

covalently binds DNA; damage causes cell to undergo apoptosis

Question 8

MOA: antimetabolites

Answer 8

prevent nucleic acid synthesis thus inhibiting cell replication; analogs of endogenous precursors of DNA and RNA

Question 9

blocks dihydrofolate reductase

Answer 9

methotrexate

Question 10

MOA: antitumor anitbiotics

Answer 10

intercalation of DNA

Question 11

adverse reaction of anti tumor antibiotics (doxorubicin)

Answer 11

cardiotoxicity; CHF

Question 12

MOA: mitotic inhibitors

Answer 12

interfere w/ microtubule assembly/disassembly

Question 13

blocks tubulin polymerization

Answer 13

vincristine

Question 14

block tubulin depolymerization

Answer 14

paclitaxel

Question 15

cause permanent strand breaks by prevuing resealing of nicked DNA

Answer 15

irinotecan (topoisomerase inhibitors)

Question 16

monoclonal antibody

Answer 16

Rituximab

Question 17

tyrosine kinase inhibitor

Answer 17

Imatinib

Question 18

side effects

Answer 18

myelosupression (thrombocytopenia, neutropenia, anemia)
GI effects (stomatitis, diarrhea, N/V)
alopecia
secondary tumors